부산대학교 도서관

Dissolution profiles of cyclosporin A available in the form of soft gelatin capsules from four manufacturers were studied and characterized by the similarity and dissimilarity coefficients. No similarity was found between the dissolution profiles of the original preparation and three generics, although the integral dissolution indices of all preparations at the end point (60 min) were quite comparable. Therefore, determination of the dissolution index alone does not provide adequate evaluation of the bioequivalence of generics.