부산대학교 도서관

This paper aims to address the cellular toxicity of ultra-pure zinc oxide (ZnO) and titanium dioxide (TiO2) nanoparticles (NPs) frequently employed in sunscreens as inorganic physical sun blockers to provide protection against adverse effects of ultraviolet (UV) radiation including UVB (290-320 nm) and UVA (320-400 nm). In consideration that the production and the use of inorganic NPs have aroused many concerns and controversies regarding their safety and toxicity, it is very important to directly investigate a main problem related to the intrinsic/inherent toxicity of these NPs and/or their incompatibility with biological objects(cancer cells and adults zebrafish). In the present study, we took advantage of the laser-assisted method called laser ablation for generation of ZnO and TiO2 NPs. NPs were prepared through a physical process of irradiating solid targets in liquid phase and we took UV-Vis spectrum, TEM, XRD, PL and EDAX results to prove these nanoparticles’ properties. Our results show that TiO2 NPs are essentially non-poisonous and ZnO NPs are more toxic than TiO2 NPs based on the cell viability assays. And the results for zebrafish show ZnO and TiO2 NPs are not acute because of NPs’ aggregation.