부산대학교 도서관

Background:In glycogen-rich clear cell carcinoma of the breast (GRCC) more than 90% of the neoplastic cells have glycogenated clear cytoplasm. This rare carcinoma accounts for only about 0.9-3.0% of all breast neoplasms. We report a case of typical GRCC with cytologic findings of fine needle aspiration biopsy.Case:A 35-year-old female visited our hospital complaining of a palpable left breast mass in early January 1997. A tumor approximately 2.0 cm was palpated and breast cancer was suspected by radiological examination. Cytological diagnosis of fine needle aspiration biopsy was issued as Class 4. She underwent quadrantectomy with dissection of lymph nodes on March 9. Histologically, proliferation of clear cells with glycogen accumulation in the cytoplasm was noted in both the mammary duct and infiltrating area, and the diagnosis of GRCC was made. Cytological findings were as follows: distinct cell boundary (similar to vegetable cells), clear and vacuolated or fine granular cytoplasm, round nuclei with various sizes, and single and enlarged nucleoli appearing slightly red. These cytological findings were similar to those of previously reported GRCC.Conclusion: Aspiration cytological findings of GRCC have not been well defined due to its rarity. Whether or not GRCC is a distinct entity and should be classified as a separate entity of breast neoplasms remain controversial. Cytological diagnosis of GRCC may be possible before surgery. Further study is needed to determine the diagnostic value of GRCC and its distinct features.