학술논문
Comparative Study of the Effectiveness of Cefotaxime and Cefazolin on Respiratory Tract Infection / 呼吸器感染症に対するCefotaximeとCefazolinの薬効比較試験
Document Type
Journal Article
Author
Akio AOYAGI; Akio TACHIBANA; Akira SAITO; Akira UJIIE; Atsushi SAITO; Atsushi SHIMOMURA; Eiro TSUBURA; Fumihiko UBA; Fumio MIKI; Fumio NAGAHAMA; Fusanosuke YAMASAKU; Gen TAJIMA; Genichi TANAKA; Hajimu TAKEDA; Haruhiko TOKUOMI; Harumi SHISHIDO; Hideo IKEMOTO; Hideo SASAKI; Hideyo NOGUCHI; Hirohiko NAGASAKA; Hiroichi TANIMOTO; Hiromi ASAKURA; Hiromi KATO; Hiromichi UMEDA; Hironobu IHARA; Hiroshi NAGANO; Hiroshi OKANO; Hiroshi OKUBO; Hiroyuki KOBAYASHI; Hisao KIMURA; Hisashi NAKAHATA; Ippei FUJIMORI; Izumi HAYASHI; Jingoro SHIMADA; Junzaburo KABE; Jutaro SHIMOMURA; Kaoru OKADA; Kaoru OYAMA; Kaoru SHIMADA; Katsuhiko MATSUI; Katsuhiro OKAMOTO; Katsumasa TOKUNAGA; Kazue SADAMOTO; Kazufuto FUKAYA; Kazuhiko HAGANE; Kazuhiko ITO; Kazuki MIURA; Kazuo HORIE; Kazuo SASAKI; Kazuo TAKEBE; Kazuyoshi WATANABE; Keigo MAEHARA; Keiichi NAKAGAWA; Keiji TAKAHASHI; Keiko CHO; Keimei MASHIMO; Keisuke NISHIWAKI; Keizo MATSUMOTO; Kenichi IMAMURA; Kenichi KIMURA; Kenji KUBO; Kenzo SHIOTA; Kinichi IZUMIKAWA; Kiyofumi ISHIKAWA; Kiyohito TAKAHASHI; Kiyoshi KONNO; Kiyoya IZUMI; Ko FUJII; Kohei HARA; Koichi WATANABE; Koichiro NAKADA; Kosho YOSHIKAWA; Kosuke NAKAZAWA; Kotaro OIZUMI; Koya SHIBA; Kozo MORI; Kuninori SUZUKI; Kunio KUDO; Makoto FUKUI; Makoto IMAOKA; Masahisa OMORI; Masahito KATO; Masahito OKAYASU; Masanaga TAKATO; Masanori ADACHI; Masanori MORISE; Masao NAKATOMI; Masaro KAJI; Masaru NASU; Masataka KATSU; Masatoshi IDE; Masayuki ANDO; Masumi TOMIZAWA; Michio YAMAKIDO; Michiyasu NAKANISHI; Mikihiko KUDO; Mitsuaki YOSHIOKA; Mitsuko TAKAMURA; Mitsunobu AKASHI; Mitsuo NAKAMURA; Mitsuru IWAKURA; Morikuni ABE; Noboru SHIMIZU; Nobuaki TSUZUKI; Nobuharu OE; Nobuki AOKI; Nobuo MAEKAWA; Norio KIHARA; Osamu KITAMOTO; Osamu KURIMURA; Osamu SEKINE; Otohiko KUNII; Rinzo SOEJIMA; Rokushi OKA; Ryoji OHASHI; Ryokichi TAKASUGI; Ryutaro KIUCHI; Ryuzo FUEKI; Saburo YANO; Seiichi HONMA; Seiichi MURAKAMI; Setsuo KOBAYASHI; Shigechika KADO; Shigeru MIYANO; Shigeru NAGAOKA; Shinichi MATSUO; Shinichi MORINAGA; Shinji OKUI; Shinya YASUDA; Shiro KOSAKA; Shoji YASUI; Shoko NARITA; Shuichiro YOSHIDA; Shuzo SAKAI; Sumio ARAI; Sumio YAMAOKA; Susumu SUETSUGU; Tadashi MIYAHARA; Tadashi MIYAZAWA; Tadashi TAKIGAMI; Takafumi YANO; Takamitsu KIDO; Takashi ITO; Takashi WATANABE; Takehisa YAMAJI; Takehito NAKAMURA; Takehumi KUNIEDA; Takekuni IWATA; Takeshi MASHIMA; Tamotsu TAKISHIMA; Tatsuo SUZUKI; Teruo KATAYAMA; Tetsuaki INOKUCHI; Tomohiro KANAZAWA; Toshihiko YOSHIGA; Toshikatsu KATO; Toshio FUJIOKA; Toshio HOJYO; Toshiro ODA; Toshiyuki MAEDA; Toshiyuki YAMAMOTO; Tsukasa YOSHIDA; Tsuneo MATSUBARA; Tsuneo TSUTSUMI; Tsunetoshi KOTEDA; Yasuhiro KAWABE; Yasuko YUASA; Yasumichi KATO; Yasuo MATSUOKA; Yasuo NOMURA; Yasushi YAMADA; Yasutoshi SUZUKI; Yasutsugu FUKUDA; Yoichiro ICHIKAWA; Yoji SUZUYAMA; Yomei HIRAGA; Yoshihiko MATSUDA; Yoshihiko TANO; Yoshihiro KUMASAKA; Yoshihiro TAKISHITA; Yoshihiro UEDA; Yoshimaru USUDA; Yoshio HOSHIHARA; Yoshio KINOSHITA; Yoshio KOBAYASHI; Yoshioki NIWA; Yoshiro SAWAE; Yoshiteru SHIGENO; Yoshito NIKI; Yukio NISHIMOTO; Yuruko OKAMOTO; 三木 文雄; 三浦 一樹; 上田 良弘; 下村 寿太郎; 下村 惇; 中富 昌夫; 中川 圭一; 中村 光男; 中村 武仁; 中沢 浩亮; 中田 紘一郎; 中畑 久; 中西 通泰; 丹羽 義置; 久保 研二; 二木 芳人; 井原 裕宣; 井手 政利; 今岡 誠; 今村 憲市; 今野 淳; 伊藤 和彦; 伊藤 隆; 佐々木 和夫; 佐々木 英夫; 前原 敬吾; 前川 暢夫; 前田 敏行; 副島 林造; 加地 正郎; 加藤 年克; 加藤 康道; 加藤 弘已; 加藤 政仁; 勝 正孝; 北本 治; 北条 敏夫; 原 耕平; 古川 公章; 可部 順三郎; 右馬 文彦; 吉岡 光明; 吉田 司; 吉田 秀一郎; 国井 乙彦; 国枝 武文; 城戸 啓光; 堀江 和夫; 堤 恒雄; 塩田 憲三; 大久保 滉; 大山 馨; 大森 雅久; 大橋 亮二; 大江 宣春; 大泉 耕太郎; 奥井 津二; 守永 真一; 安井 昭二; 安田 真也; 安藤 正幸; 安達 正則; 宍戸 春美; 定本 和江; 宮原 正; 宮沢 正; 宮野 滋; 富沢 磨須美; 小坂 志朗; 小林 宏行; 小林 節雄; 小林 芳夫; 小田 敏郎; 山作 房之輔; 山岡 澄夫; 山木戸 道郎; 山本 俊幸; 山田 泰史; 山路 武久; 岡 六四; 岡安 大仁; 岡本 勝博; 岡本 緩子; 岡田 薫; 岡野 弘; 岩倉 盈; 岩田 猛邦; 島田 馨; 嶋田 甚五郎; 川部 汎康; 工藤 国夫; 工藤 幹彦; 市川 洋一郎; 平賀 洋明; 張 景弘; 徳永 勝正; 徳臣 晴比古; 成田 祥耕; 斉藤 玲; 斉藤 篤; 明石 光伸; 星原 芳雄; 朝倉 裕美; 木下 与四男; 木内 隆太郎; 木原 令夫; 木村 久男; 木村 健一; 末次 勸; 本間 誠一; 村上 誠一; 松井 克彦; 松原 恒雄; 松尾 信一; 松岡 康夫; 松本 慶蔵; 松田 美彦; 林 泉; 柴 孝也; 栗村 統; 梅田 博道; 森 幸三; 森瀬 雅典; 武田 元; 武部 和夫; 氏家 昭; 永坂 博彦; 池本 秀雄; 沢江 義郎; 泉 清弥; 泉川 欣一; 深谷 一太; 清水 昇; 渡辺 一功; 渡辺 講一; 渡辺 隆; 湯浅 保子; 滝上 正; 滝下 佳寛; 滝島 任; 熊坂 義裕; 片山 鏡男; 猪口 哲彰; 田中 元一; 田島 玄; 田野 吉彦; 真下 啓明; 真嶋 武; 矢野 三郎; 矢野 敬文; 石川 清文; 福井 信; 福田 安嗣; 立花 昭生; 笛木 隆三; 籠手田 恒敏; 続木 信明; 羽金 和彦; 芳賀 敏彦; 荒井 澄夫; 薄田 芳丸; 藤井 皓; 藤岡 利生; 藤森 一平; 螺良 英郎; 西本 幸男; 西脇 敬祐; 谷本 普一; 賀戸 重充; 那須 勝; 酒井 秀造; 重野 芳輝; 野口 英世; 野村 靖郎; 金沢 知博; 鈴山 洋司; 鈴木 国功; 鈴木 康稔; 鈴木 達夫; 長岡 滋; 長浜 文夫; 長野 準; 関根 理; 阿部 守邦; 青木 信樹; 青柳 昭雄; 高杉 良吉; 高村 光子; 高橋 敬治; 高橋 清仁; 高頭 正長
Source
感染症学雑誌 / Kansenshogaku Zasshi. 1980, 54(9):471
Subject
Language
Japanese
ISSN
0387-5911
1884-569X
1884-569X
Abstract
The clinical efficacy and safety of CTX for respiratory infections were objectively studied with CEZ as the control. In principle, 2 g/day of CTX and 4 g/day of CEZ were intravenously dripinfused for 14 days.1. The rates of effectiveness for all the cases were 69.9% for CTX and 64.5% for CEZ, those for pneumonia were 70.1 % for CTX and 69.9% for CEZ, those for bacterial pneumonia were 75.9% for CTX and 75.4% for CEZ and those for the cases without pneumonia were 69.9% for CTX and 75.4 for CEZ. In the stratified analysis, the rates of effectiveness of CTX were significantly higher than those of CEZ in the cases having no underlying diseases or complications, in all the severe cases and in the cases with pneumonia.2. The rates of effectiveness evaluated by the investigators were 78.8% for CTX and 72.8% for CEZ when all the cases were considered, 82.2% for CTX and 76.0% for CEZ in pneumonia, 87.9% for CTX and 82.8% for CEZ in bacterial pneumonia and 73.2% for CTX and 66.0% for CEZ in the cases without pneumonia. CTX displayed significantly higher rates of effectiveness than CEZ in all the cases (U-test).3. CTX had generally higher rates of improvement than CEZ in individual symptoms, clinical findings and laboratory test results. Significant improvements were observed in 6 cases for CTX and in 3 cases for CEZ.4. As for bacteriological effects, CTX showed a disappearance rate of 50.0% in 2 strains of gram positive bacteria and that of 80.0% in 31 strains of gram-negative bacteria, while the corresponding rates for CEZ were 100% in 3 strains of gram-positive bacteria and 76.7% in gram-negative bacteria. Although replacement of bacteria by Pseudomonas was observed in 2 cases with CEZ, there were no such cases with CTX.5. The incidence of side effects was 3.5% for CTX and 4.1% for CEZ. Abnormal laboratory results were observed at the rate of 24.9% for CTX and 23.6% for CEZ. Side effects were all mild, including eruption and an increase in the level of transaminase, and there were no significant differences between CTX and CEZ.6. Compared with CEZ, CTX showed generally superior values in the evaluation of usefulness, but there were no, significant differences between the two.It may be concluded from these results that 2 g/day of CTX produced effects on respiratory infections which were equal to or better than the effects of CEZ, and that CTX had significantly higher rates of effectiveness than CEZ, especially in severe cases. CTX was relatively free from side effects and is considered to be useful for respiratory infections, especially for severe cases.