부산대학교 도서관

Purpose: An algorithm for early diagnosis of pancreatic cancer (PC) has yet to be established. The goal of this study was to perform a retrospective assessment of the clinical features of resected PC diagnosed during surveillance for hepatocellular carcinoma (HCC) in chronic liver disease (CLD). Materials and Methods: The subjects were 110 consecutive patients who underwent resection of PC at our hospital between January 2011 and December 2019. These patients were divided into the HCC surveillance (HS) group, comprising 16 patients diagnosed with PC during follow-up of CLD; and a non-surveillance (NS) group of the remaining 94 patients. Clinicopathological outcomes in these groups were compared retrospectively. Result: Three patients in the HS group had a history of HCC treatment. The HS group had a significantly lower proportion of patients with symptoms at diagnosis (12.5% vs. 73.4%, P<0.0001) and a significantly higher rate of resectable PC (93.7% vs. 57.4%, P=0.0020), compared to the NS group. The HS group also had a significantly lower rate of combined vascular resection (6.2% vs. 30.8%, P=0.0218), a significantly higher R0 resection rate (100.0% vs. 86.2%, P=0.0365), and a significantly higher proportion of patients in the early stage (0–IIA) at diagnosis (43.7% vs. 14.9%, P=0.0130). PC was diagnosed by imaging for HCC surveillance in 13 cases (81.3%) in the HS group, while only 5 cases (5.3%) were diagnosed radiographically in the NS group. Conclusion: HCC surveillance in CLD may contribute to detection of asymptomatic and relatively early stage PC or resectable PC. These results show the need to check both the liver and pancreas in imaging during follow-up of CLD.