학술논문
Current status of inhaled nitric oxide therapy for lung transplantation in Japan: A nationwide survey / 本邦における肺移植時の一酸化窒素（NO）ガス使用状況に関する実態調査
Document Type
Journal Article
Author
Daisuke Nakajima; Hiroshi Date; Ichiro Yoshino; Jun Nakajima; Koichi Tomoshige; Masaaki Sato; Masato Minami; Masayuki Chida; Nobuyuki Yoshiyasu; Seiichiro Sugimoto; Shinichi Toyooka; Soichiro Funaki; Sumiko Maeda; Takahiro Nakajima; Takeshi Nagayasu; Takeshi Shiraishi; Tomoshi Tsuchiya; Yasuaki Tomioka; Yoshinori Okada; Yui Watanabe; 中島 大輔; 中島 崇裕; 中島 淳; 伊達 洋至; 佐藤 雅昭; 前田 寿美子; 千田 雅之; 南 正人; 吉安 展将; 吉野 一郎; 土谷 智史; 富岡 泰章; 岡田 克典; 朝重 耕一; 杉本 誠一郎; 永安 武; 渡辺 有為; 白石 武史; 舟木 壮一郎; 豊岡 伸一
Source
日本呼吸器外科学会雑誌 / The Journal of the Japanese Association for Chest Surgery. 2022, 36(7):722
Subject
Language
Japanese
ISSN
0919-0945
1881-4158
1881-4158
Abstract
Results: During the study period, lung transplants were performed for 357 patients, among whom inhaled NO therapy was administered to 349 patients (98%). The median initial and median maximum inhaled NO doses were 10 and 20 ppm, respectively. Inhaled NO therapy was introduced during surgery and continued postoperatively in 313 patients (90%) for a median of 4 days. Significant improvements in oxygenation and decreases in pulmonary arterial pressure were observed in patients receiving inhaled NO therapy. Side effects of inhaled NO therapy, such as methemoglobinemia, were observed in 15 patients (4%), with a significant incidence in patients aged < 18 years.