학술논문
ApalcillinとCarbenicillinの慢性気道感染症に対する薬効比較試験成績 / COMPARATIVE CLINICAL STUDY BETWEEN APALCILLIN AND CARBENICILLIN AGAINST CHRONIC RESPIRATORY TRACT INFECTIONS BY WELL-CONTROLLED STUDY
Document Type
Journal Article
Author
AKIRA IKEBE; AKIRA ITO; AKIRA SAITO; AKIRA WATANABE; ATSUSHI SAITO; ATUSHI SAITO; CHIAKI FUJII; DAISUKE MIZOGUCHI; EIICHI YAMADA; EIRO TSUBURA; FUMIHIKO UBA; FUMIO MIKI; FUMIO NAGAHAMA; FUSANOSUKE YAMASAKU; FUYUHIKO HIGASHI; HAJIMU TAKEDA; HARUKO IWASAKI; HIDEO IKEMOTO; HIDEYUKI HASEGAWA; HIROICHI TANIMOTO; HIROMARO IWASAKI; HIROSHI OKUBO; HIROSHI SUZUKI; HIROYUKI KOBAYASHI; HISASHI ISHIKAWA; HISASHI TAKIZUKA; ICHIRO NAKAYAMA; IPPEI FUJIMORI; JUNICHIRO TAKESHITA; JUNKO MAKINO; JUNZABURO KABE; KAORU OYAMA; KAORU SHIMADA; KAZUFUTO FUKAYA; KAZUYOSHI WATANABE; KEIGO MAEHARA; KEIICHI NAKAGAWA; KEIMEI MASHIMO; KEIZO MATSUMOTO; KENICHI OKAYAMA; KENTARO WATANABE; KENZO SHIOTA; KIHACHIRO SHIMIZU; KINICHI IZUMIKAWA; KIYOSHI KONNO; KOHEI HARA; KOHKICHI FUKUSHIMA; KOJI YOSHIO; KOTARO OIZUMI; KUNIO IMADAKA; KYOSHU GO; MAKIO URIHARA; MASAFUMI HAYASHIDA; MASAMOTO NAKANO; MASAO NAKATOMI; MASARU KOYAMA; MASARU NASU; MASARU ONUMA; MASATAKA KATSU; MASATO NAKANO; MASUMI TOMIZAWA; MICHIAKI KAWANO; MICHIHIDE KAWAI; MICHINORI KOHNO; MICHIYASU NAKANISHI; NATSUO NISHIZAWA; NOBUHIRO HORIUCHI; NOBUKI AOKI; NOBUO MAEKAWA; NOBUOKI MORI; OSAMU KITAMOTO; OSAMU SEKINE; OTOHIKO KUNII; RINZO SOEJIMA; ROKUSHI OKA; RYOICHI MURAKI; RYUICHIRO YAMAZAKI; RYUSAKU SHIMIZU; SABURO KITAURA; SAKAE KAN; SAKIMORI YAMAGUCHI; SHINGO ARAI; SHINJI MOTOJIMA; SHINJI OKUI; SHIRO KAWASHIMA; SHOICHI KAWAMURA; SHOICHIRO IRIMAJIRI; TAKASHI INAMATSU; TAKEHIRO TSUJIMOTO; TAKEHITO NAKABAYASHI; TAKESHI KIKUCHI; TATSUO SUZUKI; TOMOHIRO KAWANO; TOSHIHIRO FUJII; TOSHIYUKI YAMAMOTO; TSUNEO TSUTSUMI; YASUMICHI KATO; YASUSHI UEDA; YASUTOSHI SUZUKI; YOSHICHIKA KANAI; YOSHIHIKO TANO; YOSHIHIRO UEDA; YOSHIO UZUKA; YOSHIRO SAWAE; YUICHI KAGAMI; YUKIO GOTO; YURUKO OKAMOTO; 三木 文雄; 上田 泰; 上田 良弘; 中富 昌夫; 中山 一朗; 中川 圭一; 中林 武仁; 中西 通泰; 中野 昌人; 中野 正心; 今野 淳; 今高 国夫; 伊藤 章; 入交 昭一郎; 前原 敬吾; 前川 暢夫; 副島 林造; 加藤 康道; 勝 正孝; 北本 治; 北浦 三郎; 原 耕平; 可部 順三郎; 右馬 文彦; 吉雄 幸治; 呉 京修; 国井 乙彦; 堀内 信宏; 堤 恒雄; 塩田 憲三; 大久保 滉; 大山 馨; 大泉 耕太郎; 奥井 津二; 宇塚 良夫; 富沢 磨須美; 小山 優; 小林 宏行; 小沼 賢; 山作 房之輔; 山口 防人; 山崎 隆一郎; 山本 俊幸; 山田 栄一; 岡 六四; 岡山 謙一; 岡本 緩子; 岩崎 博円; 岩崎 温子; 島田 馨; 川合 馗英; 川島 士郎; 後藤 幸夫; 斎藤 厚; 斎藤 玲; 斎藤 篤; 本島 新治; 村木 良一; 東 冬彦; 松本 慶蔵; 林田 正文; 栗原 牧夫; 森 信興; 武田 元; 池本 秀雄; 池辺 璋; 沢江 義郎; 河村 正一; 河野 知弘; 河野 通律; 河野 通昭; 泉川 欣一; 深谷 一太; 清水 喜八郎; 清水 隆作; 渡辺 一功; 渡辺 健太郎; 渡辺 彰; 溝口 大輔; 滝塚 久志; 牧野 純子; 田野 吉彦; 真下 啓明; 石川 寿; 福島 孝吉; 稲松 孝思; 竹下 潤一郎; 荒井 信吾; 菅 栄; 菊地 武志; 藤井 俊宥; 藤井 千秋; 藤森 一平; 螺良 英郎; 西沢 夏生; 谷本 普一; 辻本 兵博; 那須 勝; 金井 豊親; 鈴木 寛; 鈴木 康稔; 鈴木 達夫; 鏡 雄一; 長浜 文雄; 長谷川 英之; 関根 理; 青木 信樹
Source
CHEMOTHERAPY. 1978, 26(6):762
Subject
Language
Japanese
ISSN
0009-3165
1884-5894
1884-5894
Abstract
For the purpose of comparison of the therapeutic effects and side effects between Apalcillin (APPC) and Carbenicillin (CBPC), a comparative clinical study was carried out in 142 patients with chronic respiratory tract infections at 31 institutions in Japan.Either of APPC or CBPC was assigned to each patient at random. Administration was performed by intravenous drip infusions for a fixed period of 14 days and the daily dosage was fixed at 2g (APPC) or 4 g (CBPC).A committee consisting of several physicians who had not been informed of the name of actually given drug, made a judgement on the severity, therapeutic results and presence or absence of side effects in each patient based on the detailed subjective and objective symptoms, laboratory findings and chest X-ray films. Subsequently, the key code for the drug administered to each patient was opened and a statistical analysis was carried out by a comparison between two groups (APPC group and CBPC group) with respect to background factors, clinical effectiveness, bacteriological effectiveness, degree of improvement and side effects.Out of 142 cases originally admitted to the trial, 16 cases were excluded bacause of failure to meet the initially established protocol and 126 cases (67 from APPC group and 59 from CBPC group) were used for the analysis of effectiveness while the analysis of side effects was done in 141 cases (75 from APPC group and 66 from CBPC group).It was indicated that there was no significant difference between the two groups regarding background factors except body weight, PaCO2 and ESR. Clinical effects of APPC were good in 40 cases, fair in 7 cases, poor in 19 cases and unknown in 1 case and those of CBPC were excellent in 3 cases, good in 32 cases, fair in 15 cases, poor in 7 cases and unknown in 2 cases. There was no statistically significant difference between the both groups concerning clinical effectiveness, bacteriological effectiveness and the degree of improvement. As to the incidence of side effects, no statistically significant difference was observed between the both groups.