부산대학교 도서관

Background: We report the cytological findings and results of HPV investigation of a case of papillary squamous cell carcinoma (PSCC), which is a rate variant of squamous cell carcinoma of the uterine cervix.Case: A 36-year-old female had a papillary tumor of the uterine cervix which showed exogenous growth and easy bleeding. It was clinically diagnosed as malignant neoplasm; however, cytological findings were interpreted as severe dysplasia or squamous cell carcinoma in situ (CIS). There were no obvious findings indicating invasive carcinoma.Histologically, the resected specimens showed a papillary tumor with thin fibrovascular core and a part of stromal invasion. The diagnosis of PSCC (FIGO I b 2) was made. We investigated HPV by a PCR method and detected 16 HPV virus (high-risk type).Conclusion: In general, it is difficult to define stromal invasion in PSCC by preoperative evaluation including cytology and biopsy, and PSCC therefore tends to be underdiagnosed as CIS. Nevertheless, it may be possible to reach the correct diagnosis of PSCC by both cytological findings, i. e. abundant tumor cells, rather large tumor cell clusters, cytological atypia of each tumor cells, and histological findings of biopsy material whenever PSCC is included in the differential diagnosis by gross and colposcopic findings.