부산대학교 도서관

The purpose of this study is to elucidate the velocity of O2 and CO2 uptake and release of perfluorochemical (PFC) emulsion, which is a candidate for an artificial erythrocyte substitute because of its high O2 and CO2 solubility.The velocity was measured with a polarographic continuous flow method and aa spectropnotometric stopped flow method.These results were as follows:1. The O2 uptake and rtlease of 20% PFC emulsion finished within 26msec., whose rate was more rapid than that of human erytnrocyte.2. With a small quantity of carbonic anhydrase, the CO2 uptake and release of 5% PFC emulsion finished within 8, 5msec.These results suggest that PFC emulsion may be useful as artificial O2 and CO2 carrier in circulation, i. e. artificial erythrocyte substitute.