부산대학교 도서관

Background:Osteoarthritis (OA) is a degenerative disease characterized by joint damage, inadequate healing response, and progressive deterioration of joint structure, often affecting the knee and / or hip joint. PRP is an autologous preparation containing concentrated bioactive factors4. It is easily derived from the blood by the simple technique of centrifugation. Materials and Methods: 100 patients presenting to the Orthopedics outpatient department with symptomatic knee osteoarthritis of grade 1-3 of Kellgren-Lawrence classification6 were selected for the study according to inclusion and exclusion criteria, out of which 20 patients lost to follow up, so 80 patients included in this study. All 80 patients were subjected to Western Ontario and McMaster Universities Osteoarthritis Index Score (WOMAC) for pain evaluation and functional outcome. Results: At pre-treatment, the mean WOMAC score was lowest in grade 1 patients while it was highest in grade 3 patients. In post-treatment evaluation, the mean WOMAC scores obtained in grade 1 and grade 2 patients showed a reducing trend at each follow-up visit. Kellgren-Lawrence grade 1 values reduced from 76.269 at pre-treatment evaluation to 38.423 after 12 months of treatment. Similarly, in grade 2 patients, the mean WOMAC reduced from 77.830 at pre-treatment to 47.617 after 12 months. This signified an improvement observed in the patients' symptomatology. However, no such decline was seen in the mean WOMAC scores of grade 3 patients. The pre-treatment 78.143 and post-treatment 78.000 values remained almost the same. The results obtained concluded that injection of autologous PRP is indeed an effective treatment modality for Kellgren-Lawrence grade 1 and grade 2 osteoarthritis at least for the 12 months, and had satisfactory effects in reducing pain and stiffness, as well as in restoring joint function. In advanced stages (Kellgren-Lawrence grade 3) of the disease, not much improvement was seen even after PRP therapy. Conclusion: Injection of autologous PRP is indeed an effective treatment modality forKellgren-Lawrence grade 1 and grade 2 osteoarthritis. It had satisfactory effects in reducing pain and stiffness, as well as in restoring joint function. PRP is a safe, simple, economic, and efficacious modality in the treatment of Kellgren-Lawrence grade 1 and grade 2 osteoarthritis. Keywords: PRP (Platelet Rich Plasma), PPP (Platelet Poor Plasma), WOMAC SCORE (Western Ontario and McMaster Universities Osteoarthritis Index Score) OA (Osteoartheritis).
INTRODUCTION Around the world, osteoarthritis is the foremost cause of physical morbidity. It also causes a marked decrease in quality of life.[1] Patients present with symptoms of pain, swelling and [...]