부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2006.02.044 Byline: Aaron W. Grossman (a)(b)(c), Nicholas M. Elisseou (a), Brandon C. McKinney (a), William T. Greenough (a)(b)(d) Keywords: Plasticity; Hippocampus; Spine shape; Activity dependent; Development Abbreviations: FMRP, fragile X mental retardation protein; LTP, long-term potentiation; LTD, long-term depression; FXS, Fragile X syndrome Abstract: Fragile X syndrome (FXS) is a common form of mental retardation caused by the absence of functional fragile X mental retardation protein (FMRP). FXS is associated with elevated density and length of dendritic spines, as well as an immature-appearing distribution profile of spine morphologies in the neocortex. Mice that lack FMRP (Fmr1 knockout mice) exhibit a similar phenotype in the neocortex, suggesting that FMRP is important for dendritic spine maturation and pruning. Examination of Golgi-stained pyramidal cells in hippocampal subfield CA1 of adult Fmr1 knockout mice reveals longer spines than controls and a morphology profile that, while essentially opposite of that described in the Fmr1 knockout neocortex, appears similarly immature. This finding strongly suggests that FMRP is required for the processes of spine maturation and pruning in multiple brain regions and that the specific pathology depends on the cellular context. Author Affiliation: (a) Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA (b) Neuroscience Graduate Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA (c) Medical Scholars Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA (d) Departments of Psychology, Psychiatry and Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA Article History: Accepted 7 February 2006