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To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1349-7006.2007.00582.x Byline: Yutaka Tamada (1,2), Hideyuki Takeuchi (1), Nao Suzuki (3), Nobuyuki Susumu (2), Daisuke Aoki (2), Tatsuro Irimura (1,4) Abstract: A monoclonal antibody (mAb) MY.1E12 was applied to detect MUC1 with sialylated glycans in a total of 55 formalin-fixed, paraffin-embedded surgical specimens of ovarian clear cell adenocarcinomas. A reverse correlation between the binding levels of this mAb and patient survival was demonstrated. To examine the role of MUC1 in ovarian clear cell carcinomas, two cDNA encoding MUC1 were transfected into ES-2 ovarian clear cell carcinoma cells. By comparing these cells, the role of MUC1 in tumorigenicity, chemosensitivity and survival under anoikis conditions were assessed. The results indicate that MUC1 expressed on ovarian clear cell carcinoma cells is causally involved in the malignant behavior. (Cancer Sci 2007; 98: 1586-1591) Author Affiliation: (1)Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033; (2)Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582; (3)Department of Obstetrics and Gynecology, School of Medicine, St Marianna University, Kanagawa 216-8511, Japan Article History: (Received March 22, 2007/Revised May 25, 2007/2nd Revised June 28, 2007/Accepted June 29, 2007/Online publication August 16, 2007) Article note: (4) To whom correspondence should be addressed. E-mail: irimura@mol.f.u-tokyo.ac.jp