학술논문
Optimising the diagnostic accuracy of First post-contrAst SubtracTed breast MRI (FAST MRI) through interpretation-training: a multicentre e-learning study, mapping the learning curve of NHS Breast Screening Programme (NHSBSP) mammogram readers using an enriched dataset
Document Type
Report
Author
Jones, Lyn I.; Marshall, Andrea; Geach, Rebecca; Elangovan, Premkumar; O'Flynn, Elizabeth; Timlin, Tony; McKeown-Keegan, Sadie; Rose, Janice; Vinnicombe, Sarah; Taylor-Phillips, Sian; Halling-Brown, Mark; Dunn, Janet A.; Alison, Clare; Atkinson, Karen; Barta, Miklos; Beckett, Gemini; Betancourt, Claudia; Bramwell, Julie; Brown, Holly; Burt, Helen; Cann, Louise; Carter, Nick; Cartledge, Claire; Ceney, Jane; Clark, Gillian; Cornford, Eleanor; Cullimore, Elizabeth; Curtis, Siân; Dalgliesh, Diana; Delve, Jonathon; Doyle, Sarah; Duncan, Alison; Elbert, Holly; Fearn, Sarah; Foy, Christopher; Friedrich, Zsolt; Ghiasvand, Hesam; Gifford, John; Godden, Dagmar; Goldthorpe, Zoe; Gomes, Sandra; Goud, Narayan Aradhana; Gray, Rosie; Harding, Sam A.; Henning, Kristin; Hobson, Lucinda; Hulme, Claire; Hynam, Paula; Imane, El Sanharawi; Jackson, Emma; Jaffa, Asif; Jhalla, Ragini; Jenkin, Margaret; Jones, Thomas William; Kamangari, Nahid; Kaur, Vandana; Kingsnorth, Beckie; Klimczak, Katherine; Kutt, Elisabeth; Litton, Karen; Lloyd, Simon; Lyburn, Iain; Mahatma, Anjum; Mankelow, Anna; Massey, Helen; Matthews, Helen; McFeely, Karis; McLachlan, Clare; McWilliams, Sarah; Mohammadi, Shahrooz; Moody, Alice; Muscat, Elizabeth; Muthyala, Sreenivas; Perrin, Sarah; Peters, Alison; Pocklington, Alice; Preston, Elizabeth; Rai, Jasvinder; Robson, Jo; Salter, Corri; Scanlon, Toni; Shrestha, Anuma; Sidebottom, Richard; Sinclair, Mary; Singamaneni, Sravya; Steel, Jim; Stephenson, Lesley; Stewart-Maggs, Sam; Stubbs, Cheryl; Taylor, Michelle; Taylor, Victoria; Taylor-Fry, Olivia; Toth, Erika; Trumble, Matthew; Valencia, Alexandra; Vincent, Frances; Wang, Anna; Warren, Lucy; Watkin, Sharon; Widdison, Sue; Williams, Jennifer; Wookey, Jennifer
Source
Breast Cancer Research. May 28, 2024, Vol. 26 Issue 1
Subject
Language
English
ISSN
1465-5411
Abstract
Background Abbreviated breast MRI (FAST MRI) is being introduced into clinical practice to screen women with mammographically dense breasts or with a personal history of breast cancer. This study aimed to optimise diagnostic accuracy through the adaptation of interpretation-training. Methods A FAST MRI interpretation-training programme (short presentations and guided hands-on workstation teaching) was adapted to provide additional training during the assessment task (interpretation of an enriched dataset of 125 FAST MRI scans) by giving readers feedback about the true outcome of each scan immediately after each scan was interpreted (formative assessment). Reader interaction with the FAST MRI scans used developed software (RiViewer) that recorded reader opinions and reading times for each scan. The training programme was additionally adapted for remote e-learning delivery. Study design Prospective, blinded interpretation of an enriched dataset by multiple readers. Results 43 mammogram readers completed the training, 22 who interpreted breast MRI in their clinical role (Group 1) and 21 who did not (Group 2). Overall sensitivity was 83% (95%CI 81-84%; 1994/2408), specificity 94% (95%CI 93-94%; 7806/8338), readers' agreement with the true outcome kappa = 0.75 (95%CI 0.74-0.77) and diagnostic odds ratio = 70.67 (95%CI 61.59-81.09). Group 1 readers showed similar sensitivity (84%) to Group 2 (82% p = 0.14), but slightly higher specificity (94% v. 93%, p = 0.001). Concordance with the ground truth increased significantly with the number of FAST MRI scans read through the formative assessment task (p = 0.002) but by differing amounts depending on whether or not a reader had previously attended FAST MRI training (interaction p = 0.02). Concordance with the ground truth was significantly associated with reading batch size (p = 0.02), tending to worsen when more than 50 scans were read per batch. Group 1 took a median of 56 seconds (range 8-47,466) to interpret each FAST MRI scan compared with 78 (14-22,830, p < 0.0001) for Group 2. Conclusions Provision of immediate feedback to mammogram readers during the assessment test set reading task increased specificity for FAST MRI interpretation and achieved high diagnostic accuracy. Optimal reading-batch size for FAST MRI was 50 reads per batch. Trial registration (25/09/2019): ISRCTN16624917. Keywords: FAST MRI, Abbreviated breast MRI, Breast cancer, Screening, Formative assessment, Medical education, Diagnostic accuracy, e-learning
Author(s): Lyn I. Jones[sup.1], Andrea Marshall[sup.2], Rebecca Geach[sup.1], Premkumar Elangovan[sup.3], Elizabeth O'Flynn[sup.4], Tony Timlin[sup.1], Sadie McKeown-Keegan[sup.1], Janice Rose[sup.5], Sarah Vinnicombe[sup.6], Sian Taylor-Phillips[sup.2], Mark Halling-Brown[sup.3], Janet A. Dunn[sup.2], Clare Alison, Karen [...]
Author(s): Lyn I. Jones[sup.1], Andrea Marshall[sup.2], Rebecca Geach[sup.1], Premkumar Elangovan[sup.3], Elizabeth O'Flynn[sup.4], Tony Timlin[sup.1], Sadie McKeown-Keegan[sup.1], Janice Rose[sup.5], Sarah Vinnicombe[sup.6], Sian Taylor-Phillips[sup.2], Mark Halling-Brown[sup.3], Janet A. Dunn[sup.2], Clare Alison, Karen [...]