학술논문
Evolution of marsupial and other vertebrate thyroxine-binding plasma proteins
Document Type
Academic Journal
Author
Source
The American Journal of Physiology. April, 1994, Vol. 266 Issue 4, pR1359, 12 p.
Subject
Language
ISSN
0002-9513
Abstract
Electrophoresis and autoradiography, used to study the binding of radioactive thyrosine to proteins in the plasma of vertebrates, revealed that in all cases of fish, birds, eutherians such as placental mammals, marsupials, monotremes, reptiles and amphibians, the albumin was the thyroxin carrier in the blood. The blood samples of eutherians, diprotodont marsupials and birds had traces of transthyretin bound with thyroxine and blood samples of mammals had globulin bound throxine. A change of transthyretin pre-mRNA splicing during evolution was revealed by an analysis of the NH2 terminal sequence.