부산대학교 도서관

INTRODUCTION The arterial bifurcation is the common site for intracranial aneurysms (IAs) (1,2). The complex hemodynamic status at widened arterial bifurcations was considered closely correlated with aneurysm formation (3). in [...]
Previous studies have reported that intracranial aneurysms frequently occur adjacent to the medial gap. However, the role of the medial gap in aneurysm formation is controversial. We designed this study to explore the potential role of the medial gap in aneurysm formation. Widened artery bifurcations with or without medial gaps were microsurgically created and pathologically stained in the carotid arteries of 30 rats. Numerical artery bifurcation models were constructed, and bidirectional fluid-solid interaction analyses were performed. Animal experiments showed that the apexes of widened bifurcations with a medial gap were prone to being insulted by blood flow compared to those without a medial gap. The bidirectional fluid-solid interaction analyses indicated that artery bifurcations with the medial gap exhibited higher wall shear stress (WSS) and von Mises stress (VMS) at the apex of the bifurcation. The disparity of stress between the gap and no-gap model was larger for widened bifurcations, peaking at 180[degrees] with a maximum of 1.9 folds. The maximum VMS and relatively high WSS were located at the junction between the medial gap and the adjacent arterial wall. Our results suggest that the medial gap at the widened arterial bifurcation may promote aneurysm formation. Key Words: Aneurysm, Animal model, Hemodynamics, Medial gap.