학술논문
Effects of Glucagon-like Peptide-1 on the Reproductive Axis in Healthy Men
CLINICAL RESEARCH ARTICLE
CLINICAL RESEARCH ARTICLE
Document Type
Report
Author
Izzi-Engbeaya, Chioma; Jones, Sophie; Crustna, Yoshibye; Machenahalli, Pratibha C.; Papadopoulou, Deborah; Modi, Manish; Panayi, Christos; Starikova, Jessica; Eng, Pei Chia; Phylactou, Maria; Mills, Edouard; Yang, Lisa; Ratnasabapathy, Risheka; Sykes, Mark; Plumptre, Isabella; Coumbe, Ben; Wing, Victoria C.; Pacuszka, Ewa; Bech, Paul; Minnion, James; Tharakan, George; Tan, Tricia; Veldhuis, Johannes; Abbara, Ali; Comninos, Alexander N.; Dhillo, Waljit S.
Source
Journal of Clinical Endocrinology & Metabolism. April 2020, Vol. 105 Issue 4, p1119, 7 p.
Subject
Language
English
ISSN
0021-972X
Abstract
Reproduction and metabolism are interconnected, but the mediators of the interaction between these physiological processes are poorly understood (1). Up to 40% of men with obesity and/or type 2 diabetes [...]
Context: Glucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As GLP-1 receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary to determine the effects of GLP-1 on the reproductive system in humans. Objective: To investigate the effects of GLP-1 administration on the reproductive axis in humans. Design: Single-blind, randomized, placebo-controlled crossover study. Setting: Clinical Research Facility, Imperial College Healthcare NHS Trust. Participants: Eighteen healthy men (mean age 24.7 [+ or -] 0.1years, mean BMI 22.1 [+ or -] 0.4kg/[m.sup.2]). Intervention: Eight-hour intravenous infusion of 0.8 pmol/kg/min GLP-1 or rate-matched vehicle infusion. Main Outcome Measures: Number of luteinizing hormone (LH) pulses, LH, follicle-stimulating hormone (FSH), and testosterone levels. Results: The number of LH pulses (number of LH pulses/500 min: vehicle 4.2 [+ or -] 0.4, GLP1 4.5 [+ or -] 0.3, P = 0.46), LH area under the curve (AUC) (vehicle 1518 [+ or -] 88min.IU/L, GLP-1 1524 [+ or -] 101min.IU/L, P = 0.95), follicle-stimulating hormone AUC (vehicle 1210 [+ or -] 112 min IU/L, GLP-1 1216 [+ or -] 112 min IU/L, P = 0.86), and testosterone AUC (vehicle 10893 [+ or -] 615 min nmol/L, GLP-1 11088 [+ or -] 792 min nmol/L, P = 0.77) did not significantly differ during vehicle and GLP-1 administration. Glucagon-like peptide-1 significantly reduced food intake (vehicle 15.7 [+ or -] 1.3 kcal/kg, GLP-1 13.4 [+ or -] 1.3 kcal/kg, P = 0.01). Conclusions: In contrast to the animal literature, our data demonstrate that acute GLP-1 administration does not affect reproductive hormone secretion in healthy men. (J Clin Endocrinol Metab 105: 1119-1125, 2020) Key Words: glucagon-like peptide-1, luteinizing hormone, follicle stimulating hormone, testosterone, reproduction
Context: Glucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As GLP-1 receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary to determine the effects of GLP-1 on the reproductive system in humans. Objective: To investigate the effects of GLP-1 administration on the reproductive axis in humans. Design: Single-blind, randomized, placebo-controlled crossover study. Setting: Clinical Research Facility, Imperial College Healthcare NHS Trust. Participants: Eighteen healthy men (mean age 24.7 [+ or -] 0.1years, mean BMI 22.1 [+ or -] 0.4kg/[m.sup.2]). Intervention: Eight-hour intravenous infusion of 0.8 pmol/kg/min GLP-1 or rate-matched vehicle infusion. Main Outcome Measures: Number of luteinizing hormone (LH) pulses, LH, follicle-stimulating hormone (FSH), and testosterone levels. Results: The number of LH pulses (number of LH pulses/500 min: vehicle 4.2 [+ or -] 0.4, GLP1 4.5 [+ or -] 0.3, P = 0.46), LH area under the curve (AUC) (vehicle 1518 [+ or -] 88min.IU/L, GLP-1 1524 [+ or -] 101min.IU/L, P = 0.95), follicle-stimulating hormone AUC (vehicle 1210 [+ or -] 112 min IU/L, GLP-1 1216 [+ or -] 112 min IU/L, P = 0.86), and testosterone AUC (vehicle 10893 [+ or -] 615 min nmol/L, GLP-1 11088 [+ or -] 792 min nmol/L, P = 0.77) did not significantly differ during vehicle and GLP-1 administration. Glucagon-like peptide-1 significantly reduced food intake (vehicle 15.7 [+ or -] 1.3 kcal/kg, GLP-1 13.4 [+ or -] 1.3 kcal/kg, P = 0.01). Conclusions: In contrast to the animal literature, our data demonstrate that acute GLP-1 administration does not affect reproductive hormone secretion in healthy men. (J Clin Endocrinol Metab 105: 1119-1125, 2020) Key Words: glucagon-like peptide-1, luteinizing hormone, follicle stimulating hormone, testosterone, reproduction