학술논문
Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus
Research Article
Research Article
Document Type
Report
Author
Rosinski, Jenna R.; Raasch, Lauren E.; Barros Tiburcio, Patrick; Breitbach, Meghan E.; Shepherd, Phoenix M.; Yamamoto, Keisuke; Razo, Elaina; Krabbe, Nicholas P.; Bliss, Mason I.; Richardson, Alexander D.; Einwalter, Morgan A.; Weiler, Andrea M.; Sneed, Emily L.; Fuchs, Kerri B.; Zeng, Xiankun; Noguchi, Kevin K.; Morgan, Terry K.; Alberts, Alexandra J.; Antony, Kathleen M.; Kabakov, Sabrina; Ausderau, Karla K.; Bohm, Ellie K.; Pritchard, Julia C.; Spanton, Rachel V.; Ver Hoove, James N.; Kim, Charlene B. Y.; Nork, T. Michael; Katz, Alex W.; Rasmussen, Carol A.; Hartman, Amy; Mejia, Andres; Basu, Puja; Simmons, Heather A.; Eickhoff, Jens C.; Friedrich, Thomas C.; Aliota, Matthew T.; Mohr, Emma L.; Dudley, Dawn M.; O'Connor, David H.; Newman, Christina M.
Source
PLoS Pathogens. March 28, 2023, Vol. 19 Issue 3, e1011282
Subject
Language
English
ISSN
1553-7366
Abstract
Author(s): Jenna R. Rosinski 1, Lauren E. Raasch 1, Patrick Barros Tiburcio 1, Meghan E. Breitbach 1, Phoenix M. Shepherd 1, Keisuke Yamamoto 1, Elaina Razo 2, Nicholas P. Krabbe [...]
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.