학술논문
Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma
Document Type
Report
Author
Johnson, Douglas B.; Atkins, Michael B.; Hennessy, Cassandra; Wise-Draper, Trisha; Heilman, Hannah; Awosika, Joy; Bakouny, Ziad; Labaki, Chris; Saliby, Renee Maria; Hwang, Clara; Singh, Sunny R. K.; Balanchivadze, Nino; Friese, Christopher R.; Fecher, Leslie A.; Yoon, James J.; Hayes-Lattin, Brandon; Bilen, Mehmet A.; Castellano, Cecilia A.; Lyman, Gary H.; Tachiki, Lisa; Shah, Sumit A.; Glover, Michael J.; Flora, Daniel B.; Wulff-Burchfield, Elizabeth; Kasi, Anup; Abbasi, Saqib H.; Farmakiotis, Dimitrios; Viera, Kendra; Klein, Elizabeth J.; Weissman, Lisa B.; Jani, Chinmay; Puc, Matthew; Fahey, Catherine C.; Reuben, Daniel Y.; Mishra, Sanjay; Beeghly-Fadiel, Alicia; French, Benjamin; Warner, Jeremy L.; Reid, Sonya A.; Brown, Alaina J.; Cheng, Alex; Croessmann, Sarah; Davis, Elizabeth J.; Enriquez, Kyle T.; Gillaspie, Erin A.; Hausrath, Daniel; Li, Xuanyi; Slosky, David A.; Solorzano, Carmen C.; Tucker, Matthew D.; Vega-Luna, Karen; Wang, Lucy L.; Wise-Draper, Trisha M.; Ahmad, Syed A.; Grover, Punita; Gulati, Shuchi; Kharofa, Jordan; Latif, Tahir; Marcum, Michelle; Sohal, Davendra P. S.; Zamulko, Olga; Choueiri, Toni K.; Connors, Jean M.; Demetri, George D.; Duma, Narjust; Freeman, Dory A.; Giordano, Antonio; Morgans, Alicia K.; Nohria, Anju; Saliby, Renee-Maria; Schmidt, Andrew L.; Van Allen, Eliezer M.; Xu, Wenxin; Zon, Rebecca L.; Gadgeel, Shirish M.; Tejwani, Sheela; Boldt, Anne; Cohen, Aaron M.; McWeeney, Shannon; Nemecek, Eneida R.; Williamson, Staci P.; Ravindranathan, Deepak; Graber, Jerome J.; Grivas, Petros; Hawley, Jessica E.; Loggers, Elizabeth T.; Lynch, Ryan C.; Nakasone, Elizabeth S.; Schweizer, Michael T.; Vinayak, Shaveta; Wagner, Michael J.; Yeh, Albert; Cabebe, Elwyn C.; Jha, Alokkumar; Khaki, Ali Raza; Schapira, Lidia; Wu, Julie Tsu-Yu; Kloecker, Goetz; Logan, Barbara B.; Mandapakala, Chaitanya; Rock, Crosby D.; Arvanitis, Panos; Egan, Pamela C.; Khan, Hina; Olszewski, Adam J.; Vieira, Kendra; Weissmann, Lisa B.; Bhatt, Padmanabh S.; Mariano, Melissa G.; Thomson, Carey C.; Carducci, Theresa M.; Goldsmith, Karen J.; Van Loon, Susan; Alexander, Mariam; Matar, Sara; Mushtaq, Sarah; Stockerl-Goldstein, Keith E.; Butt, Omar; Fiala, Mark A.; Henderson, Jeffrey P.; Monahan, Ryan S.; Zhou, Alice Y.; Lammers, Philip E.; Revankar, Sanjay G.; Del Prete, Salvatore A.; Bar, Michael H.; Gulati, Anthony P.; Lo, K. M. Steve; Rose, Suzanne J.; Stratton, Jamie; Weinstein, Paul L.; Gupta, Shilpa; Pennell, Nathan A.; Ahluwalia, Manmeet S.; Dawsey, Scott J.; Lemmon, Christopher A.; Nizam, Amanda; Sharifi, Nima; Hoppenot, Claire; Li, Ang; Halabi, Susan; Dzimitrowicz, Hannah; Zhang, Tian; Goyal, Sharad; Huynh-Le, Minh-Phuong; Yu, Peter Paul; Clement, Jessica M.; Daher, Ahmad; Dailey, Mark E.; Elias, Rawad; Jayaraj, Asha; Hsu, Emily; Menendez, Alvaro G.; Serrano, Oscar K.; Accordino, Melissa K.; Bhutani, Divaya; Hershman, Dawn; Ingham, Matthew A.; Schwartz, Gary K.; Bernicker, Eric H.; Deeken, John F.; Shafer, Danielle; Ruíz-García, Erika; Ramirez, Ana; Vilar-Compte, Diana; Lewis, Mark A.; Rhodes, Terence D.; Gill, David M.; Low, Clarke A.; Mashru, Sandeep H.; Mansoor, Abdul-Hai; Lewis, Grant C.; Smith, Stephanie J.; Zaren, Howard A.; Nagaraj, Gayathri; Akhtari, Mojtaba; Castillo, Dan R.; Lau, Eric; Reeves, Mark E.; Berg, Stephanie; Knox, Natalie; O'Connor, Timothy E.; Durbin, Eric B.; Kulkarni, Amit A.; Nelson, Heather H.; Sachs, Zohar; Rosovsky, Rachel P.; Reynolds, Kerry L.; Bardia, Aditya; Boland, Genevieve; Gainor, Justin F.; Zubiri, Leyre; Halfdanarson, Thorvardur R.; Bekaii-Saab, Tanios S.; Desai, Aakash; Riaz, Irbaz B.; Shah, Surbhi; Smith, Katherine E.; Williams, Colt; Bouganim, Nathaniel; Elkrief, Arielle; Panasci, Justin; Vinh, Donald C.; Riely, Gregory J.; Belenkaya, Rimma; Philip, John; Faller, Bryan; McKay, Rana R.; Ajmera, Archana; Brouha, Sharon S.; Choi, Sharon; Hsiao, Albert; Kligerman, Seth; Nonato, Taylor K.; Blau, Erin G. Reid Sibel; Jhawar, Sachin R.; Addison, Daniel; Chen, James L.; Gatti-Mays, Margaret E.; Karivedu, Vidhya; Palmer, Joshua D.; Stover, Daniel G.; Wall, Sarah; Williams, Nicole O.; Joshi, Monika; Polimera, Hyma V.; Pomerantz, Lauren D.; Rovito, Marc A.; Griffiths, Elizabeth A.; Advani, Pragati G.; Puzanov, Igor; Jabbour, Salma K.; Misdary, Christian F.; Shah, Mansi R.; Batist, Gerald; Cook, Erin; Dutra, Miriam Santos; Ferrario, Cristiano; Miller, Wilson H.; Bashir, Babar; McNair, Christopher; Mahmood, Sana Z.; Mico, Vasil; Rivera, Andrea Verghese; Edwin, Natasha C.; Smits, Melissa; Doroshow, Deborah B.; Galsky, Matthew D.; Wotman, Michael; Fazio, Alyson; Fu, Julie C.; Huber, Kathryn E.; Sueyoshi, Mark H.; Koshkin, Vadim S.; Borno, Hala T.; Kwon, Daniel H.; Small, Eric J.; Zhang, Sylvia; Rubinstein, Samuel M.; Wood, William A.; Andermann, Tessa M.; Jensen, Christopher; Bowles, Daniel W.; Geiger, Christoper L.; Feldman, Lawrence E.; Hoskins, Kent F.; Gantt, Gerald; Liu, Li C.; Khan, Mahir; Nguyen, Ryan H.; Pasquinelli, Mary; Schwartz, Candice; Venepalli, Neeta K.; Mavromatis, Blanche H.; Bijjula, Ragneel R.; Zaman, Qamar U.; Aboulafiam, David M.; Schroeder, Brett A.; Topaloglu, Umit; Alimohamed, Saif I.; Moore, Joan K.; Peddi, Prakash; Rosen, Lane R.; McCollough, Briana Barrow; Hafez, Navid; Herbst, Roy; LoRusso, Patricia; Lustberg, Maryam B.; Masters, Tyler; Stratton, Catherine
Source
BMC Cancer. March 23, 2023, Vol. 23 Issue 1
Subject
Language
English
ISSN
1471-2407
Abstract
Introduction COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associated with COVID-19 severity among patients with melanoma, particularly assessing outcomes of patients on active targeted or immune therapy. Methods Using the COVID-19 and Cancer Consortium (CCC19) registry, we identified 307 patients with melanoma diagnosed with COVID-19. We used multivariable models to assess demographic, cancer-related, and treatment-related factors associated with COVID-19 severity on a 6-level ordinal severity scale. We assessed whether treatment was associated with increased cardiac or pulmonary dysfunction among hospitalized patients and assessed mortality among patients with a history of melanoma compared with other cancer survivors. Results Of 307 patients, 52 received immunotherapy (17%), and 32 targeted therapy (10%) in the previous 3 months. Using multivariable analyses, these treatments were not associated with COVID-19 severity (immunotherapy OR 0.51, 95% CI 0.19 - 1.39; targeted therapy OR 1.89, 95% CI 0.64 - 5.55). Among hospitalized patients, no signals of increased cardiac or pulmonary organ dysfunction, as measured by troponin, brain natriuretic peptide, and oxygenation were noted. Patients with a history of melanoma had similar 90-day mortality compared with other cancer survivors (OR 1.21, 95% CI 0.62 - 2.35). Conclusions Melanoma therapies did not appear to be associated with increased severity of COVID-19 or worsening organ dysfunction. Patients with history of melanoma had similar 90-day survival following COVID-19 compared with other cancer survivors. Keywords: COVID-19, Melanoma, Immune therapy, Targeted therapy, Cancer
Author(s): Douglas B. Johnson[sup.1] , Michael B. Atkins[sup.2] , Cassandra Hennessy[sup.1] , Trisha Wise-Draper[sup.3] , Hannah Heilman[sup.3] , Joy Awosika[sup.3] , Ziad Bakouny[sup.4] , Chris Labaki[sup.4] , Renee Maria Saliby[sup.4] [...]
Author(s): Douglas B. Johnson[sup.1] , Michael B. Atkins[sup.2] , Cassandra Hennessy[sup.1] , Trisha Wise-Draper[sup.3] , Hannah Heilman[sup.3] , Joy Awosika[sup.3] , Ziad Bakouny[sup.4] , Chris Labaki[sup.4] , Renee Maria Saliby[sup.4] [...]