학술논문
Analysis of the Role of Plasma 25-Hydroxyvitamin D Levels in Survival Outcomes in Patients from the Phase III MPACT Trial of Metastatic Pancreatic Cancer
Brief Communications
Brief Communications
Document Type
Academic Journal
Author
Source
The Oncologist. April 2021, Vol. 26 Issue 4, pe704, 6 p.
Subject
Language
English
ISSN
1083-7159
Abstract
Introduction The use of biomarkers has allowed for the identification of patients who may experience improved efficacy with certain treatments; however, few such biomarkers exist for pancreatic cancer. On the [...]
Background. We examined overall survival (OS) outcomes based on plasma 25-hydroxyvitamin D [25(OH)D] levels in this post hoc analysis of the phase III MPACT trial of metastatic pancreatic cancer. Materials and Methods. Patients were subdivided based on 25(OH)D level: sufficient ([greater than or equal to] 30 ng/mL), relatively insufficient (20- Results. Of 861 patients randomized in MPACT, 422 were included in this analysis. In the all-patients group, the median OS among those with insufficient, relatively insufficient, and sufficient 25(OH)D levels was 7.9, 9.4, and 7.8 months, respectively. No statistically significant OS difference was observed with relatively insufficient (p = .227) or sufficient (p = .740) versus insufficient 25(OH)D levels or with sufficient vs relatively insufficient (p = .301) 25(OH)D levels. Conclusion. No association was observed between plasma 25(OH)D levels and survival. Further investigations are needed to understand any role of vitamin D in pancreatic cancer. Clinical trial identification number. NCT00844649.
Background. We examined overall survival (OS) outcomes based on plasma 25-hydroxyvitamin D [25(OH)D] levels in this post hoc analysis of the phase III MPACT trial of metastatic pancreatic cancer. Materials and Methods. Patients were subdivided based on 25(OH)D level: sufficient ([greater than or equal to] 30 ng/mL), relatively insufficient (20- Results. Of 861 patients randomized in MPACT, 422 were included in this analysis. In the all-patients group, the median OS among those with insufficient, relatively insufficient, and sufficient 25(OH)D levels was 7.9, 9.4, and 7.8 months, respectively. No statistically significant OS difference was observed with relatively insufficient (p = .227) or sufficient (p = .740) versus insufficient 25(OH)D levels or with sufficient vs relatively insufficient (p = .301) 25(OH)D levels. Conclusion. No association was observed between plasma 25(OH)D levels and survival. Further investigations are needed to understand any role of vitamin D in pancreatic cancer. Clinical trial identification number. NCT00844649.