학술논문
Dexamethasone activates expression of the PDGF-alpha receptor and induces lung fibroblast proliferation
Document Type
Academic Journal
Author
Source
The American Journal of Physiology. April, 1998, Vol. 274 Issue 4, pL499, 9 p.
Subject
Language
ISSN
0002-9513
Abstract
The mechanism of dexamethasone-induced lung fibroblast proliferation was investigated in vitro using cultures of mouse and rat fibroblasts. Addition of dexamethasone induces the proliferation of these cells. This response is blocked with the use of a polyclonal antibody directed against the AB isoform of the platelet-derived growth factor (PDGF). Dexamethasone also upregulates the expression of the PDGF receptor. These results suggests that PDGF plays a role in the fibroblast proliferative response induced by dexamethasone.