학술논문
Central Nervous System Tuberculosis in a Murine Model: Neurotropic Strains or a New Pathway of Infection?
Document Type
Report
Author
Rembao-Bojórquez, Daniel; Sánchez-Garibay, Carlos; Salinas-Lara, Citlaltepetl; Marquina-Castillo, Brenda; Letechipía-Salcedo, Adriana; Castillón-Benavides, Omar Jorge; Galván-Arzate, Sonia; Gómez-López, Marcos; Jiménez-Zamudio, Luis Antonio; Soto-Rojas, Luis O.; Tena-Suck, Martha Lilia; Nava, Porfirio; Fernández-Vargas, Omar Eduardo; Coria-Medrano, Adrian; Hernández-Pando, Rogelio
Source
Pathogens. December, 2023, Vol. 13 Issue 1
Subject
Language
English
ISSN
2076-0817
Abstract
Tuberculosis (TB) of the central nervous system (CNS) is a lethal and incapacitating disease. Several studies have been performed to understand the mechanism of bacterial arrival to CNS, however, it remains unclear. Although the interaction of the host, the pathogen, and the environment trigger the course of the disease, in TB the characteristics of these factors seem to be more relevant in the genesis of the clinical features of each patient. We previously tested three mycobacterial clinical isolates with distinctive genotypes obtained from the cerebrospinal fluid of patients with meningeal TB and showed that these strains disseminated extensively to the brain after intratracheal inoculation and pulmonary infection in BALB/c mice. In this present study, BALB/c mice were infected through the intranasal route. One of these strains reaches the olfactory bulb at the early stage of the infection and infects the brain before the lungs, but the histological study of the nasal mucosa did not show any alteration. This observation suggests that some mycobacteria strains can arrive directly at the brain, apparently toward the olfactory nerve after infecting the nasal mucosa, and guides us to study in more detail during mycobacteria infection the nasal mucosa, the associated connective tissue, and nervous structures of the cribriform plate, which connect the nasal cavity with the olfactory bulb.
Author(s): Daniel Rembao-Bojórquez [1,2,†]; Carlos Sánchez-Garibay [1,3,4,5,†]; Citlaltepetl Salinas-Lara (corresponding author) [1,3,4,6,*]; Brenda Marquina-Castillo [7]; Adriana Letechipía-Salcedo [8]; Omar Jorge Castillón-Benavides [9]; Sonia Galván-Arzate [10]; Marcos Gómez-López [11]; Luis Antonio [...]
Author(s): Daniel Rembao-Bojórquez [1,2,†]; Carlos Sánchez-Garibay [1,3,4,5,†]; Citlaltepetl Salinas-Lara (corresponding author) [1,3,4,6,*]; Brenda Marquina-Castillo [7]; Adriana Letechipía-Salcedo [8]; Omar Jorge Castillón-Benavides [9]; Sonia Galván-Arzate [10]; Marcos Gómez-López [11]; Luis Antonio [...]