부산대학교 도서관

Antiphospholipid syndrome is a disease that was discovered just 25 years ago. Although clinical manifestations have been clearly described, pathogenetic mechanisms are still barely understood. A recent hypothesis involves inflammation in the setting of antiphospholipid syndrome morbidity and experimental data support the activation of a complement cascade as a pivotal event in its physiopathology. In this review, the authors will analyze the recent literature, focusing on contemporary and emerging aspects of complement-mediated disease pathogenesis, and pinpoint the clinical significance of this novel finding.
Author(s): Sara De Carolis [sup.[*]] [sup.2] , Annachiara Vitucci [sup.1] , Serafina Garofalo [sup.1] , Silvia Salvi [sup.1] , Gelsomina Del Sordo [sup.1] , Rossella Rella [sup.1] , Angela Botta [...]