학술논문
The Relationship Between N-Terminal Pro-Brain Natriuretic Peptide Level and Left Ventricular Metabolic Index in Patients with Heart Failure with Mildly Reduced Ejection Fraction
Research Article
Research Article
Document Type
Academic Journal
Author
Source
Ejournal of Cardiovascular Medicine. March 2022, Vol. 10 Issue 1, p4, 8 p.
Subject
Language
English
Abstract
Introduction The plasma concentration of the cardiac natriuretic peptide, N-terminal pro-brain natriuretic peptide (NT-proBNP), is tightly correlated with cardiac function (1). The increased release of NT-proBNP into the bloodstream by [...]
Objectives: It has been determined that mortality and hospitalization rates due to cardiovascular diseases are higher in patients with left ventricular hypertrophy (LVH). In addition, LVH has been shown to be an independent risk factor for heart failure (HF). Previous studies in this area have focused more on preserved and low ejection fraction HF. Therefore, we aimed to contribute to the literature by investigating the relationship between N-terminal pro-brain natriuretic peptide level (NT-proBNP) and left ventricular metabolic index (LVMI) in heart failure with mildly reduced ejection fraction (HFmrEF). Materials and Methods: Between January 2018 and October 2021, 213 patients diagnosed with heart failure with mildly reduced ejection fraction were included in the study. This study was designed as cross-sectional. The patients were divided into two groups according to their gender, as those with normal and abnormal LVMI. Pearson's correlations were used to assess the correlations between LVMI and NT-proBNP. A ROC curve was plotted to determine the diagnostic reliability of plasma concentration of NT-proBNP on LVMI. Results: There were 90 patients in Group 1 (patients with normal LVMI) and 123 patients in Group 2 (patients with high LVMI). The mean LVMI value was 94.37 ([+ or -] 11.10) g/[m.sup.2] in Group 1 and 119.64 ([+ or -] 15.90) g/[m.sup.2] in Group 2. The mean NT-proBNP level was found to be 941.57 ([+ or -] 1190.81) pg/ml. NT-proBNP levels were statistically significantly higher in Group 2 than in Group 1 (1138.49 [+ or -] 1330.7 vs. 672.46 [+ or -] 907.52, p=0.005). The relationship between NT-proBNP (941.57 [+ or -] 1190.81 pg/mL) levels and LVMI (108.96 [+ or -] 18.81 g/[m.sup.2]) was tested by the Pearson correlation. A moderate, positive and significant relationship was found between these variables [r (211) = 0.368, p342 pg/mL had 57% sensitivity and 58% specificity [receiver operating characteristic (ROC) area under curve: 0.620, 95% CI: 0.544-0.695, p=0.003] for determining LVMI. Conclusion: In patients with heart failure with mildly reduced ejection fraction, high NT-proBNP levels can predict LVMI elevation, which is an indicator of LVH. In this patient group, especially female gender and renal dysfunction may be risk factors for high LVMI. Keywords: Mildly reduced ejection fraction, NT-proBNP, left ventricular metabolic index
Objectives: It has been determined that mortality and hospitalization rates due to cardiovascular diseases are higher in patients with left ventricular hypertrophy (LVH). In addition, LVH has been shown to be an independent risk factor for heart failure (HF). Previous studies in this area have focused more on preserved and low ejection fraction HF. Therefore, we aimed to contribute to the literature by investigating the relationship between N-terminal pro-brain natriuretic peptide level (NT-proBNP) and left ventricular metabolic index (LVMI) in heart failure with mildly reduced ejection fraction (HFmrEF). Materials and Methods: Between January 2018 and October 2021, 213 patients diagnosed with heart failure with mildly reduced ejection fraction were included in the study. This study was designed as cross-sectional. The patients were divided into two groups according to their gender, as those with normal and abnormal LVMI. Pearson's correlations were used to assess the correlations between LVMI and NT-proBNP. A ROC curve was plotted to determine the diagnostic reliability of plasma concentration of NT-proBNP on LVMI. Results: There were 90 patients in Group 1 (patients with normal LVMI) and 123 patients in Group 2 (patients with high LVMI). The mean LVMI value was 94.37 ([+ or -] 11.10) g/[m.sup.2] in Group 1 and 119.64 ([+ or -] 15.90) g/[m.sup.2] in Group 2. The mean NT-proBNP level was found to be 941.57 ([+ or -] 1190.81) pg/ml. NT-proBNP levels were statistically significantly higher in Group 2 than in Group 1 (1138.49 [+ or -] 1330.7 vs. 672.46 [+ or -] 907.52, p=0.005). The relationship between NT-proBNP (941.57 [+ or -] 1190.81 pg/mL) levels and LVMI (108.96 [+ or -] 18.81 g/[m.sup.2]) was tested by the Pearson correlation. A moderate, positive and significant relationship was found between these variables [r (211) = 0.368, p342 pg/mL had 57% sensitivity and 58% specificity [receiver operating characteristic (ROC) area under curve: 0.620, 95% CI: 0.544-0.695, p=0.003] for determining LVMI. Conclusion: In patients with heart failure with mildly reduced ejection fraction, high NT-proBNP levels can predict LVMI elevation, which is an indicator of LVH. In this patient group, especially female gender and renal dysfunction may be risk factors for high LVMI. Keywords: Mildly reduced ejection fraction, NT-proBNP, left ventricular metabolic index