학술논문
Influence of phenytoin and valproate on thalamocortical evoked potentials and their paired-pulse potentiation
Document Type
Text
Author
Source
Physiological research | 1992 Volume:41 | Number:6
Subject
Language
English
Abstract
The action of phenytoin and valproate on thalamocortical responses was studied in adult rats. Single responses were not influenced by either drug. Paired-pulse potentiation of the initial components (first positive and first negative) observed with intervals from 50 to 200 ms under control conditions was abolished by phenytoin (60 mg/kg i.p.) but only moderately influenced by valproate (400 mg/kg i.p.). Paired-pulse potentiation of thalamocortical phenomena cannot be put into connection with the generation of the spike-and-wave rhythm.