학술논문

Dense Mapping of Intracellular Diffusion and Drift from Single-Particle Tracking Data Analysis
Document Type
Conference
Source
ICASSP 2020 - 2020 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) Acoustics, Speech and Signal Processing (ICASSP), ICASSP 2020 - 2020 IEEE International Conference on. :966-970 May, 2020
Subject
Signal Processing and Analysis
Tracking
Signal processing
Biology
Trajectory
Spatiotemporal phenomena
Kernel
Speech processing
Diffusion
drift
mapping
classification
single-particle tracking
Language
ISSN
2379-190X
Abstract
It is of primary interest for biologists to be able to visualize the dynamics of proteins within the cell. In this paper, we propose a new mapping method to robustly estimate dynamics in the entire cell from particle tracks. To obtain satisfying diffusion and drift maps, we use a spatiotemporal kernel estimator. Trajectory classification data is used as input and allows to automatically label particle movements into three classes: confined motion (or subdiffusion), Brownian motion, and directed motion (or superdiffusion). We then use this information to calculate diffusion coefficient and drift maps separately on each class of motion.