학술논문

Image processing challenges in the creation of spatiotemporal gene expression atlases of developing embryos
Document Type
Conference
Source
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE. :6841-6844 Aug, 2011
Subject
Bioengineering
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Computing and Processing
Signal Processing and Analysis
Gene expression
Embryo
Three dimensional displays
Microscopy
Animals
Language
ISSN
1557-170X
1094-687X
1558-4615
Abstract
To properly understand and model animal embryogenesis it is crucial to obtain detailed measurements, both in time and space, about their gene expression domains and cell dynamics. Such challenge has been confronted in recent years by a surge of atlases which integrate a statistically relevant number of different individuals to get robust, complete information about their spatiotemporal locations of gene patterns. This paper will discuss the fundamental image analysis strategies required to build such models and the most common problems found along the way. We also discuss the main challenges and future goals in the field.