학술논문
Modeling the cellular kinetics of the antiviral agents PMEA and PMPA
Document Type
Conference
Author
Source
Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in medicine and biology Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE. 5:1903-1904 vol.5 1996
Subject
Language
Abstract
The cellular kinetics of the antiviral nucleoside analogs PMEA and PMPA were modeled using intracellular measurements of the phosphonate analogs and their mono- and diphosphate derivatives, obtained following systemic administration of the parent compounds in monkeys. By decoupling the systemic disposition processes from the cellular events, a model describing the kinetics in lymphoid and red blood cells was developed.