부산대학교 도서관

The incidence of tissue injury is predominantly increasing globally as it accounts about half of the world's annual expenditure. Certain type of chronic wounds is extremely tough to eradicate as the existing therapeutic approaches are inadequate. In recent years, tissue engineering construct promoted the closure of chronic wounds, but the shortcomings such as complexity, cost and less patient compliance limited their application in clinical practice. Currently emerging Nano-drug carriers prolong drug release, protect drug from degradation and improve skin retention, also controlled release of antibiotic reduces the frequency of drug administration and thus reduces the risk of developing resistance. Hence the combination of nanomaterial with tissue engineering construct would lead to development of novel biomaterials for accelerated wound closure. Among various Nano-drug carriers, niosomes comprised of non-ionic surfactant-based vesicles formed by self-assembly of amphiphiles in aqueous environment possess unique features such as high stability, low cost, less laborious preparatory method and easy storage, good penetration with ability to trap both hydrophilic and lipophilic drugs. Thus, the niosomes would serve as an alternative to phospholipid-containing vesicles. In conclusion, the objective of study is to prepare niosomes and to develop the scaffold impregnated with niosomes for controlled delivery of relevant therapeutics which would reduce or eradicate the bacterial load in wound and hence accelerates the tissue repair.