학술논문
The association between viral load and concurrent human papillomavirus infection at the genital and anal sites of young women and the impact of vaccination
Document Type
article
Author
Kahren van Eer; Ihsane Laâbi; Birgit H.B. van Benthem; Renske D.M. Steenbergen; Audrey J. King; D. Adema; R. Buist-Arkema; A. Beerens; D. Luijt; S. Meijer; J. Schirm; M. Peeters; J. Rossen; H. Verbakel; P. van Esch; J. Verweij; A. van der Eijk; R. Huisman; C. Kerkhof; H. Korff; M. Schutten; J. Velzing; F. Verduyn-Lunel; S. Lakbiach; P. van Rosmalen; R. Schuurman; E. Doorn; L. Masthoff; E. Pannekoek; V. Sigurdsson; D. Abma; K. Adams; S. Bruisten; I. Linde; P. Oostvogel; C. Touwen; W. Vermeulen; A. Brink; J. Nelissen; P. Wolffs; N. Duijvendijk; P. Schneeberger; M. Dinnissen van Poppel; W. Melchers; Y. Poort; M.Hooghiemstra Izore; H. Huisman; J. Weel; F. Bosma; F. Geeraedts; I. Polman; P.van Goor Isala; M. Wolfhagen; C. de Mooij; E. van Koolwijk; M. Peters; C. Swanink; R. Tiemessen; T. van Zwet; J. Janssen; M. Pelsers; W. de Waal; G. Aalfs; J. Kiewiet; P. Sanders; H. van Buel- Bruins; C. van Bokhoven-Rombouts; P. Cornelissen; M. Kersten; C. van Ruitenbeek; I. Molenaar; M. Bugter; H. Götz; M. Illidge-Onder de Linden; M. Mattijssen; J. Stam; E. Swaders; F. de Groot; F. Postma; E. Brouwers; A. Niekamp; M. Smit; A. Botraby; D. Bukasa; C. de Haan; P. Hut-van Vliet; T. Taconis; M. de Graas; I. Hondelink; C. Kampman; A. Gelissen-Hansen; I. de Koning; H. van Kruchten; M. van de Pas; H. Fennema; T. Heijman; A. Hogewoning; A. van Leeuwen; M. van Rooijen; F. Neienhuijsen; M. Pelgrim
Source
Tumour Virus Research, Vol 13, Iss , Pp 200233- (2022)
Subject
Language
English
ISSN
2666-6790
Abstract
Concurrent genital-anal human papillomavirus (HPV) infections may impose an increased anal cancer risk in women with HPV-related genital lesions. High viral load may facilitate genital-anal HPV concurrence. Genital and anal HPV is reduced by a bivalent HPV16/18 vaccine, yet the effect on concurrent genital-anal HPV remains unclear.This study analyzed viral load in concurrent genital-anal HPV infections, relative to genital-only and anal-only HPV infections and the impact of vaccination in young women. We included 1074 women, who provided both genital and anal swabs. HPV detection and genotyping was performed using the SPF10-DEIA-LiPA25. HPV copy numbers were measured with type-specific qPCRs and corrected for cellular content to obtain the viral load.Concurrent genital-anal HPV often had significantly higher genital viral load (0.09–371 c/cell) than genital-only HPV (3.17E-04-15.9 c/cell, p