학술논문
Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity
Document Type
article
Author
Source
Radiation Oncology, Vol 14, Iss 1, Pp 1-11 (2019)
Subject
Language
English
ISSN
1748-717X
Abstract
Abstract Background Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conversely, proteomics approaches are not much developed, despite their advantages. Methods We used the isobaric tags for relative and absolute quantitation (iTRAQ) proteomic approach to analyze differences in protein expression levels in ex-vivo irradiated (8 Gy) T lymphocytes from patients with grade ≥ 2 radiation-induced breast fibrosis (grade ≥ 2 bf+) and patients with grade