학술논문
MAIT cells regulate NK cell-mediated tumor immunity
Document Type
article
Author
Emma V. Petley; Hui-Fern Koay; Melissa A. Henderson; Kevin Sek; Kirsten L. Todd; Simon P. Keam; Junyun Lai; Imran G. House; Jasmine Li; Magnus Zethoven; Amanda X. Y. Chen; Amanda J. Oliver; Jessica Michie; Andrew J. Freeman; Lauren Giuffrida; Jack D. Chan; Angela Pizzolla; Jeffrey Y. W. Mak; Timothy R. McCulloch; Fernando Souza-Fonseca-Guimaraes; Conor J. Kearney; Rosemary Millen; Robert G. Ramsay; Nicholas D. Huntington; James McCluskey; Jane Oliaro; David P. Fairlie; Paul J. Neeson; Dale I. Godfrey; Paul A. Beavis; Phillip K. Darcy
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance NK-dependent anti-cancer immunity in mice, thereby hinting a new avenue for cancer therapy.