학술논문
The Tehran longitudinal family-based cardiometabolic cohort study sheds new light on dyslipidemia transmission patterns
Document Type
article
Author
Mahdi Akbarzadeh; Parisa Riahi; Amir Hossein Saeidian; Maryam Zarkesh; Sajedeh Masjoudi; Sara Asgarian; Kamran Guity; Hamed Moheimani; Homayoon Masoudi; Mahmoud Amiri Roudbar; Davood Khalili; Farhad Hosseinpanah; Maryam Barzin; Carolyn T. Hogan; Hakon Hakonarson; Mehdi Hedayati; Maryam S. Daneshpour; Fereidoun Azizi
Source
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Dyslipidemia, as a metabolic risk factor, with the strongest and most heritable independent cause of cardiovascular diseases worldwide. We investigated the familial transmission patterns of dyslipidemia through a longitudinal family-based cohort, the Tehran Cardiometabolic Genetic Study (TCGS) in Iran. We enrolled 18,729 individuals (45% were males) aged > 18 years (mean: 38.15 (15.82)) and observed them over five 3-year follow-up periods. We evaluated the serum concentrations of total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol with the first measurement among longitudinal measures and the average measurements (AM) of the five periods. Heritability analysis was conducted using a mixed-effect framework with likelihood-based and Bayesian approaches. The periodic prevalence and heritability of dyslipidemia were estimated to be 65.7 and 42%, respectively. The likelihood of an individual having at least one dyslipidemic parent reveals an OR = 6.94 (CI 5.28–9.30) compared to those who do not have dyslipidemic parents. The most considerable intraclass correlation of family members was for the same-sex siblings, with ICC ~ 25.5%. For serum concentrations, heritability ranged from 33.64 to 60.95%. Taken together, these findings demonstrate that familial transmission of dyslipidemia in the Tehran population is strong, especially within the same-gender siblings. According to previous reports, the heritability of dyslipidemia in this population is considerably higher than the global average.