학술논문
Whole Genome Sequence Dataset of Mycobacterium tuberculosis Strains from Patients of Campania Region
Document Type
article
Author
Veronica Folliero; Carlo Ferravante; Valentina Iovane; Annamaria Salvati; Laura Crescenzo; Rossella Perna; Giusy Corvino; Maria T. Della Rocca; Vittorio Panetta; Alessandro Tranfa; Giuseppe Greco; Teresa Baldoni; Ugo Pagnini; Emiliana Finamore; Giorgio Giurato; Giovanni Nassa; Mariagrazia Coppola; Luigi Atripaldi; Rita Greco; Annamaria D’Argenio; Maria Grazia Foti; Rosamaria Abate; Annalisa Del Giudice; Bruno Sarnelli; Alessandro Weisz; Giuseppe Iovane; Renato Pinto; Gianluigi Franci; Massimiliano Galdiero
Source
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Subject
Language
English
ISSN
2052-4463
Abstract
Abstract Tuberculosis (TB) is one of the deadliest infectious disorders in the world. To effectively TB manage, an essential step is to gain insight into the lineage of Mycobacterium tuberculosis (MTB) and the distribution of drug resistance. Although the Campania region is declared a cluster area for the infection, to contribute to the effort to understand TB evolution and transmission, still poorly known, we have generated a dataset of 159 genomes of MTB strains, from Campania region collected during 2018–2021, obtained from the analysis of whole genome sequence. The results show that the most frequent MTB lineage is the 4 according for 129 strains (81.11%). Regarding drug resistance, 139 strains (87.4%) were classified as multi susceptible, while the remaining 20 (12.58%) showed drug resistance. Among the drug-resistance strains, 8 were isoniazid-resistant MTB, 4 multidrug-resistant MTB, while only one was classified as pre-extensively drug-resistant MTB. This dataset expands the existing available knowledge on drug resistance and evolution of MTB, contributing to further TB-related genomics studies to improve the management of this disease.