학술논문
FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation
Document Type
article
Author
Joshua I. Warrick; Wenhuo Hu; Hironobu Yamashita; Vonn Walter; Lauren Shuman; Jenna M. Craig; Lan L. Gellert; Mauro A. A. Castro; A. Gordon Robertson; Fengshen Kuo; Irina Ostrovnaya; Judy Sarungbam; Ying-bei Chen; Anuradha Gopalan; Sahussapont J. Sirintrapun; Samson W. Fine; Satish K. Tickoo; Kwanghee Kim; Jasmine Thomas; Nagar Karan; Sizhi Paul Gao; Timothy N. Clinton; Andrew T. Lenis; Timothy A. Chan; Zhiyu Chen; Manisha Rao; Travis J. Hollman; Yanyun Li; Nicholas D. Socci; Shweta Chavan; Agnes Viale; Neeman Mohibullah; Bernard H. Bochner; Eugene J. Pietzak; Min Yuen Teo; Gopa Iyer; Jonathan E. Rosenberg; Dean F. Bajorin; Matthew Kaag; Suzanne B. Merrill; Monika Joshi; Rosalyn Adam; John A. Taylor; Peter E. Clark; Jay D. Raman; Victor E. Reuter; Yu Chen; Samuel A. Funt; David B. Solit; David J. DeGraff; Hikmat A. Al-Ahmadie
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Bladder cancer can often exhibit genomic and morphological heterogeneity. Here, the authors use genomics analysis to show lineage plasticity of bladder cancers with squamous differentiation, and identify key transcription factors related to this morphological and immune heterogeneity.