학술논문
Electrochemical investigations of unexplored anthraquinones and their DNA binding
Document Type
article
Author
Source
Journal of Electrochemical Science and Engineering, Vol 3, Iss 1, Pp 19-27 (2013)
Subject
Language
English
ISSN
1847-9286
Abstract
The redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans on the voltammetric response of anthraquinones. The electrode reaction mechanism was suggested on the basis of cyclic and differential pulse voltammetric results. The effect of DNA on anthraquinones was also probed at physiological pH which could lead to further investigation of possible citotoxic activity in vitro. The results revealed that anthraquinones interact with DNA more strongly than the clinically used anticancer drug, epirubicin.