학술논문
Circulating SMRP and CA‐125 before and after pleurectomy decortication for pleural mesothelioma
Document Type
article
Author
Source
Thoracic Cancer, Vol 15, Iss 15, Pp 1237-1245 (2024)
Subject
Language
English
ISSN
1759-7714
1759-7706
1759-7706
Abstract
Abstract Background Tumor recurrence remains the main barrier to survival after surgery for pleural mesothelioma (PM). Soluble mesothelin‐related protein (SMRP) and cancer antigen 125 (CA‐125) are established blood‐based biomarkers for monitoring PM. We prospectively studied the utility of these biomarkers after pleurectomy decortication (PD). Methods Patients who underwent PD and achieved complete macroscopic resection with available preoperative SMRP levels were included. Tumor marker levels were determined within 60 days of three timepoints: (1) preoperation, (2) post‐operation, and (3) recurrence. Results Of 356 evaluable patients, 276 (78%) had recurrence by the end of follow‐up interval. Elevated preoperative SMRP levels were associated with epithelioid histology (p