학술논문
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer
Document Type
article
Author
Ming Chen; Runzhe Chen; Ying Jin; Jun Li; Xin Hu; Jiexin Zhang; Junya Fujimoto; Shawna M. Hubert; Carl M. Gay; Bo Zhu; Yanhua Tian; Nicholas McGranahan; Won-Chul Lee; Julie George; Xiao Hu; Yamei Chen; Meijuan Wu; Carmen Behrens; Chi-Wan Chow; Hoa H. N. Pham; Junya Fukuoka; Jia Wu; Edwin Roger Parra; Latasha D. Little; Curtis Gumbs; Xingzhi Song; Chang-Jiun Wu; Lixia Diao; Qi Wang; Robert Cardnell; Jianhua Zhang; Jing Wang; Xiuning Le; Don L. Gibbons; John V. Heymach; J. Jack Lee; William N. William; Chao Cheng; Bonnie Glisson; Ignacio Wistuba; P. Andrew Futreal; Roman K. Thomas; Alexandre Reuben; Lauren A. Byers; Jianjun Zhang
Source
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a cold and heterogeneous T cell repertoire.