학술논문
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
Document Type
article
Author
Hin Chu; Bingjie Hu; Xiner Huang; Yue Chai; Dongyan Zhou; Yixin Wang; Huiping Shuai; Dong Yang; Yuxin Hou; Xi Zhang; Terrence Tsz-Tai Yuen; Jian-Piao Cai; Anna Jinxia Zhang; Jie Zhou; Shuofeng Yuan; Kelvin Kai-Wang To; Ivy Hau-Yee Chan; Ko-Yung Sit; Dominic Chi-Chung Foo; Ian Yu-Hong Wong; Ada Tsui-Lin Ng; Tan To Cheung; Simon Ying-Kit Law; Wing-Kuk Au; Melinda A. Brindley; Zhiwei Chen; Kin-Hang Kok; Jasper Fuk-Woo Chan; Kwok-Yung Yuen
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.