학술논문
Temporal patterns of organ dysfunction in COVID-19 patients hospitalized in the intensive care unit: A group-based multitrajectory modeling analysis
Document Type
article
Author
Jiafei Yu; Kai Zhang; Tianqi Chen; Ronghai Lin; Qijiang Chen; Chensong Chen; Minfeng Tong; Jianping Chen; Jianhua Yu; Yuhang Lou; Panpan Xu; Chao Zhong; Qianfeng Chen; Kangwei Sun; Liyuan Liu; Lanxin Cao; Cheng Zheng; Ping Wang; Qitao Chen; Qianqian Yang; Weiting Chen; Xiaofang Wang; Zuxi Yan; Xuefeng Zhang; Wei Cui; Lin Chen; Zhongheng Zhang; Gensheng Zhang
Source
International Journal of Infectious Diseases, Vol 144, Iss , Pp 107045- (2024)
Subject
Language
English
ISSN
1201-9712
Abstract
Background: The course of organ dysfunction (OD) in Corona Virus Disease 2019 (COVID-19) patients is unknown. Herein, we analyze the temporal patterns of OD in intensive care unit-admitted COVID-19 patients. Methods: Sequential organ failure assessment scores were evaluated daily within 2 weeks of admission to determine the temporal trajectory of OD using group-based multitrajectory modeling (GBMTM). Results: A total of 392 patients were enrolled with a 28-day mortality rate of 53.6%. GBMTM identified four distinct trajectories. Group 1 (mild OD, n = 64), with a median APACHE II score of 13 (IQR 9-21), had an early resolution of OD and a low mortality rate. Group 2 (moderate OD, n = 140), with a median APACHE II score of 18 (IQR 13-22), had a 28-day mortality rate of 30.0%. Group 3 (severe OD, n = 117), with a median APACHR II score of 20 (IQR 13-27), had a deterioration trend of respiratory dysfunction and a 28-day mortality rate of 69.2%. Group 4 (extremely severe OD, n = 71), with a median APACHE II score of 20 (IQR 17-27), had a significant and sustained OD affecting all organ systems and a 28-day mortality rate of 97.2%. Conclusions: Four distinct trajectories of OD were identified, and respiratory dysfunction trajectory could predict nonpulmonary OD trajectories and patient prognosis.