학술논문
Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients
Document Type
article
Author
Antonio Benito Porcaro; Nelia Amigoni; Riccardo Rizzetto; Filippo Migliorini; Alessandro Tafuri; Pierluigi Piccoli; Leone Tiso; Mario De Michele; Alberto Bianchi; Sebastian Gallina; Paola Irene Ornaghi; Rossella Orlando; Francesco Cianflone; Alessandra Gozzo; Stefano Zecchini Antoniolli; Vincenzo Lacola; Matteo Brunelli; Maria Angela Cerruto; Walter Artibani; Alessandro Antonelli
Source
Current Urology, Vol 16, Iss 4, Pp 256-261 (2022)
Subject
Language
English
ISSN
1661-7649
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00000000
Abstract
Abstract. Objectives. To test hypothesized associations between the ABO blood group (ABO-bg) system and the pathological features of prostate cancer (PCa). Material and methods. Between January 2013 and September 2019, 1173 patients underwent radical prostatectomy. Associations between ABO-bg levels and pathological features were evaluated using statistical methods. Results. Overall, 1149 consecutive patients were evaluated using the ABO-bg system, which was represented by O-bg (42.8%) and A-bg (41.3%), followed by B-bg (11.1%) and AB-bg (4.8%). Only positive surgical margins (PSMs) was correlated with ABO-bg (Pearson correlation coefficient, r = 0.071; p = 0.017), and the risk was increased in group-O (odds ratio [OR], 1.497; 95% confidence interval, 1.149–1.950; p = 0.003) versus non–O-bg. In clinical and pathological models, O-bg was at increased risk of PSM after the adjustment for prostate-specific antigen, percentage of biopsy-positive cores, and high surgical volume (adjusted OR, 1.546; 95% confidence interval, 1.180–2.026; p = 0.002); however, the adjusted OR did not change after the adjustment for tumor load and stage as well as high surgical volume. Conclusions. In clinical PCa, the risk of PSM was higher in O-bg versus non–O-bg patients after the adjustment for standard predictors. Confirmatory studies are needed to confirm the association between ABO-bg and unfavorable PCa features.