학술논문
Predictors of solid extra-hepatic non-skin cancer in liver transplant recipients and analysis of survival: A long-term follow-up study
Document Type
article
Author
Stefano Gitto; Paolo Magistri; Luca Marzi; Nicolò Mannelli; Nicola De Maria; Andrea Mega; Giovanni Vitale; Giovanna Valente; Francesco Vizzutti; Erica Villa; Fabio Marra; Pietro Andreone; Margherita Falcini; Barbara Catellani; Gian Piero Guerrini; Valentina Serra; Stefano Di Sandro; Roberto Ballarin; Guido Piai; Filippo Schepis; Marzia Margotti; Carmela Cursaro; Paolo De Simone; Stefania Petruccelli; Paola Carrai; Paolo Forte; Claudia Campani; Heinz Zoller; Fabrizio Di Benedetto
Source
Annals of Hepatology, Vol 27, Iss 3, Pp 100683- (2022)
Subject
Language
English
ISSN
1665-2681
Abstract
Introduction and objectives: De novo malignancies represent an important cause of death for liver transplant recipients. Our aim was to analyze predictors of extra-hepatic non-skin cancer (ESNSC) and the impact of ESNSC on the long-term outcome. Patients: We examined data from patients transplanted between 2000 and 2005 and followed-up in five Italian transplant clinics with a retrospective observational cohort study. Cox Regression was performed to identify predictors of ESNSC. A 1:2 cohort sub-study was developed to analyze the impact of ESNSC on 10-year survival. Results: We analyzed data from 367 subjects (median follow-up: 15 years). Patients with ESNSC (n = 47) more often developed post-LT diabetes mellitus (DM) (57.4% versus 35,9%, p = 0.004). At multivariate analysis, post-LT DM independently predicted ESNSC (HR 1.929, CI 1.029-3.616, p = 0.040). Recipients with ESNSC showed a lower 10-year survival than matched controls (46,8% versus 68,1%, p = 0.023). Conclusions: Post-LT DM seems to be a relevant risk factor for post-LT ESNSC. ESNSC could have a noteworthy impact on the long-term survival of LT recipients.