학술논문
Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance
Document Type
article
Author
Allison Barraclough; James T. England; Diego Villa; Joel Wight; Greg Hapgood; Jason Conn; Nicole Wong Doo; Eric Wenlong Li; Michael Gilbertson; Briony Shaw; Mark J. Bishton; Malik Saeed; Sumita Ratnasingam; Chathuri Abeyakoon; Geoff Chong; Shin Hnin Wai; Matthew Ku; Hui-Peng Lee; Kathryn Fleming; Constantine Tam; Genevieve Douglas; Chan Y. Cheah; Zi Yun Ng; Tukten Rolfe; Anthony K Mills; Nada Hamad; Helen Cashman; Mary Gleeson; Manjunath Narayana; Eliza A. Hawkes
Source
Haematologica, Vol 108, Iss 9 (2023)
Subject
Language
English
ISSN
0390-6078
1592-8721
1592-8721
Abstract
Grade (G) 3B follicular lymphoma (FL) is a rare FL subtype which exists on a histological continuum between ‘lowgrade’ (Grade 1, 2 and 3A FL) and diffuse large B-cell lymphoma (DLBCL) appearing to share features with each. Clinical characteristics and outcomes are poorly understood due to lack of adequate representation in prospective trials and large-scale analyses. We analyzed 157 G3BFL cases from 18 international centers, and two comparator groups; G3AFL (n=302) and DLBCL (n=548). Composite histology with DLBCL or low-grade FL occurred in approximately half of the G3BFL cases. With a median of 5 years follow-up, the overall survival and progression-free survival of G3BFL patients was better than that of DLBCL patients (P