학술논문
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
Document Type
article
Author
Wulf Tonnus; Claudia Meyer; Christian Steinebach; Alexia Belavgeni; Anne von Mässenhausen; Nadia Zamora Gonzalez; Francesca Maremonti; Florian Gembardt; Nina Himmerkus; Markus Latk; Sophie Locke; Julian Marschner; Wenjun Li; Spencer Short; Sebastian Doll; Irina Ingold; Bettina Proneth; Christoph Daniel; Nazanin Kabgani; Rafael Kramann; Stephen Motika; Paul J. Hergenrother; Stefan R. Bornstein; Christian Hugo; Jan Ulrich Becker; Kerstin Amann; Hans-Joachim Anders; Daniel Kreisel; Derek Pratt; Michael Gütschow; Marcus Conrad; Andreas Linkermann
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Necroptosis, a form of cell death, occurs in acute renal injury. Here, the authors show that ferroptosis—a form of cell death dependent on iron - also occurs during acute kidney injury, and show that an inhibitor of ferroptosis can improve survival in a mouse model of acute kidney damage.