학술논문
A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort
Document Type
article
Author
Loreta A. Kondili; Giuseppina Brancaccio; Maria Elena Tosti; Barbara Coco; Maria Giovanna Quaranta; Vincenzo Messina; Alessia Ciancio; Filomena Morisco; Valentina Cossiga; Ernesto Claar; Valerio Rosato; Marianna Ciarallo; Irene Cacciola; Francesca Romana Ponziani; Lucia Cerrito; Roberta Coppola; Francesco Longobardi; Elisa Biliotti; Alessia Rianda; Francesco Barbaro; Nicola Coppola; Maria Stanzione; Francesco Barchiesi; Stefano Fagiuoli; Mauro Viganò; Marco Massari; Francesco Paolo Russo; Alberto Ferrarese; Diletta Laccabue; Vito Di Marco; Pierluigi Blanc; Aldo Marrone; Giulia Morsica; Alessandro Federico; Donatella Ieluzzi; Alba Rocco; Francesco Giuseppe Foschi; Alessandro Soria; Ivana Maida; Luchino Chessa; Michele Milella; Elena Rosselli Del Turco; Salvatore Madonia; Liliana Chemello; Ivan Gentile; Pierluigi Toniutto; Matteo Bassetti; Lorenzo Surace; Leonardo Baiocchi; Adriano Pellicelli; Adriano De Santis; Massimo Puoti; Elisabetta Degasperi; Grazia Anna Niro; Anna Linda Zignego; Antonio Craxi; Giovanni Raimondo; Teresa Antonia Santantonio; Maurizia Rossana Brunetto; Giovanni Battista Gaeta; Alessio Aghemo; Chiara Baiguera; Pier Maria Battezzati; Sara Battistella; Maria Grazia Bavetta; Costanza Bertoni; Carolina Boni; Paola Brambilla; Antonella Bray; Federica Briano; Enrico Carmenini; Francesco Castelli; Luisa Cavalletto; Federica Cerini; Luciana Chidichimo; Elisa Colella; Giuliana Cologni; Silvia Como; Romina Corsini; Chiara Costa; Rosa Cotugno; Silvia Cretella; Fernando De Angelis; Pasqualina De Leo; Giovanni Di Perri; Elisabetta Falbo; Luigina Ferrigno; Ezio Fornasiere; Daniela Francisci; Pietro Gatti; Pietro Lampertico; Ilaria Lenci; Anna Licata; Alfredo Marzano; Antonio Mastroianni; Cesare Mazzaro; Monica Monti; Gerardo Nardone; Laura Ambra Nicolini; Nicola Passigato; Maria Bruna Pasticci; Piera Pierotti; Biagio Pinchera; Teresa Pollicino; Carmen Porcu; Giulia Quartini; Gabriele Rancatore; Mario Romeo; Maria Grazia Rumi; Annalisa Saracino; Ornella Schioppa; Ilaria Serio; Roberta Soffredini; Xhimi Tata; Marco Tizzani; Matteo Tonnini; Carlo Torti; Daniela Valenti; Serena Zaltron; Alessia Zoncada
Source
International Journal of Infectious Diseases, Vol 146, Iss , Pp 107115- (2024)
Subject
Language
English
ISSN
1201-9712
Abstract
Background and Aims: We aimed to characterize the epidemiologic and comorbidities profiles of patients with chronic Hepatitis D (CHD) followed in clinical practice in Italy and explored their interferon (IFN) eligibility. Methods: This was a cross-sectional study of the PITER cohort consisting of consecutive HBsAg-positive patients from 59 centers over the period 2019-2023. Multivariable analysis was performed by logistic regression model. Results: Of 5492 HBsAg-positive enrolled patients, 4152 (75.6%) were screened for HDV, 422 (10.2%) were anti-HDV positive. Compared with HBsAg mono-infected, anti-HDV positive patients were more often younger, non-Italians, with a history of drug use, had elevated alanine transaminase (ALT), cirrhosis, or hepatocellular carcinoma (HCC). Compared with Italians, anti-HDV positive non-Italians were younger (42.2% age ≤ 40 years vs. 2.1%; P < 0.001), more often females (males 43.0% vs. 68.6%; P < 0.001) with less frequent cirrhosis and HCC. HDV-RNA was detected in 63.2% of anti-HDV-positive patients, who were more likely to have elevated ALT, cirrhosis, and HCC. Extrahepatic comorbidities were present in 47.4% of anti-HDV positive patients and could affect the eligibility of IFN-containing therapies in at least 53.0% of patients in care. Conclusions: CHD affects young, foreign-born patients and older Italians, of whom two-thirds had cirrhosis or HCC. Comorbidities were frequent in both Italians and non-Italians and impacted eligibility for IFN.