학술논문
Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
ABCB1 encodes Multidrug Resistance Protein which promotes efflux of chemotherapeutic and targeted agents. Here, in breast and ovarian cancer the authors identify multiple transcriptional fusion partners involving ABCB1 that are associated with treatment failure and previous treatment regimens.