학술논문
Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
Document Type
article
Author
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. Here the authors show that the chloride ion channel SWELL1 and the ion exchanger NHE1 are preferentially enriched at the trailing and leading edges, respectively, of migrating cells and regulate cell volume to propel confined cells, favouring breast cancer cell extravasation and metastasis.