학술논문
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
Document Type
article
Author
Joshua D. G. Leach; Nikola Vlahov; Petros Tsantoulis; Rachel A. Ridgway; Dustin J. Flanagan; Kathryn Gilroy; Nathalie Sphyris; Ester G. Vázquez; David F. Vincent; William J. Faller; Michael C. Hodder; Alexander Raven; Sigrid Fey; Arafath K. Najumudeen; Douglas Strathdee; Colin Nixon; Mark Hughes; William Clark; Robin Shaw; S:CORT consortium; Sander R. van Hooff; David J. Huels; Jan Paul Medema; Simon T. Barry; Margaret C. Frame; Asier Unciti-Broceta; Simon J. Leedham; Gareth J. Inman; Rene Jackstadt; Barry J. Thompson; Andrew D. Campbell; Sabine Tejpar; Owen J. Sansom
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and inflammation induce the development of colonic tumours with a foetal-like phenotype.