학술논문
Characterization and impact of non‐canonical WNT signaling on outcomes of urothelial carcinoma
Document Type
article
Author
Source
Cancer Medicine, Vol 13, Iss 7, Pp n/a-n/a (2024)
Subject
Language
English
ISSN
2045-7634
Abstract
Abstract Background Non‐canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non‐canonical WNT signaling through WNT5A, ROR1, ROR2, or FZD2 expression. Methods NextGen Sequencing of DNA (592 genes or WES)/RNA (WTS) was performed for 4125 UC tumors submitted to Caris Life Sciences. High and low expression of WNT5A, ROR1, ROR2, and FZD2 was defined as ≥ top and