학술논문
Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division
Document Type
article
Author
Serena Petracchini; Daniel Hamaoui; Anne Doye; Atef Asnacios; Florian Fage; Elisa Vitiello; Martial Balland; Sebastien Janel; Frank Lafont; Mukund Gupta; Benoit Ladoux; Jerôme Gilleron; Teresa M. Maia; Francis Impens; Laurent Gagnoux-Palacios; Mads Daugaard; Poul H. Sorensen; Emmanuel Lemichez; Amel Mettouchi
Source
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Uropathogenic strains of Escherichia coli (UPEC) are a leading cause of urinary tract infections (UTIs) and invasion involves Rho GTPase members, notably Rac1, to drive actin cytoskeleton rearrangement leading to engulfment. Here, Petracchini et al. provide evidence of an ECM stiffnessmodulated role of Optineurin (OPTN), which regulates HACE1-dependant Rac1 activity and thus controls integrinmediated mechanotransduction and bacterial invasion.