학술논문
pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation
Document Type
article
Author
Olga Boix; Marion Martinez; Santiago Vidal; Marta Giménez-Alejandre; Lluís Palenzuela; Laura Lorenzo-Sanz; Laura Quevedo; Olivier Moscoso; Jorge Ruiz-Orera; Pilar Ximénez-Embún; Nikaoly Ciriaco; Paolo Nuciforo; Camille Stephan-Otto Attolini; M. Mar Albà; Javier Muñoz; Tian V. Tian; Ignacio Varela; Ana Vivancos; Santiago Ramón y Cajal; Purificación Muñoz; Carmen Rivas; María Abad
Source
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Small proteins encoded by previously assumed non-coding RNAs can have cell regulatory functions. Here the authors report that TINCR lncRNA encodes pTINCR, a ubiquitin-like protein (UBL) that promotes epithelial differentiation through the SUMOylation and activation of CDC42, and it has tumour suppressor activity in epithelial cancers.